grant
Mechanotransduction in gastrointestinal physiology
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 17 Sept 2019Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMP5-HT5-Hydroxytryptamine5HTAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AffectAirAlimentary CanalAssayAttenuatedAwardBioassayBiological AssayBuccal CavityBuccal Cavity Head and NeckCalciumCavitas OrisCell BodyCell Communication and SignalingCell DensityCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCell modelCellLineCellsCellular FunctionCellular MechanotransductionCellular PhysiologyCellular ProcessCellular biologyCellular modelChemicalsChronicChronic diarrheaConstipationConsumptionCyclic AMPDataDiagnosisDigestive TractDiseaseDisorderDistalDyspepsiaEC CellElectrophysiologyElectrophysiology (science)EndowmentEnteramineEnterochromaffinEnterochromaffin CellsEnteroendocrine CellEpithelial CellsEpitheliumEsthesiaExocytosisExposure toFunctional Gastrointestinal DisordersG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGI TractGPCRGastrointestinal MotilityGastrointestinal PhysiologyGastrointestinal TractGastrointestinal tract structureGoalsHealthHealth CareHippophaineHumanHypersensitivityImageIn SituIndigestionIntestinalIntestinal MotilityIntestinesIntracellular Communication and SignalingIon Channel GatingIon Channel GatingsIrritable Bowel SyndromeIrritable ColonKnock-outKnockoutKnowledgeKnowledge acquisitionL CellsLaboratoriesLinkLiquid substanceLocationMechanical Signal TransductionMechanical StimulationMechanicsMechanosensory TransductionMerkel CellsMerkel's ReceptorModern ManMolecularMotilityMouthMucous ColitisNeurophysiology / ElectrophysiologyNutrientOral cavityOrganoidsOrphan DiseaseOutcomeParticulatePathway interactionsPatientsPhysiologicPhysiologicalPhysiologyPiezo 2Piezo 2 ion channelPiezo2PopulationRare DiseasesRare DisorderReceptor ProteinRectumResearchRoleSensationSensorySensory ProcessSerotoninShort-Chain Fatty AcidsSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSkinSmall IntestinesSolidStimulusStrains Cell LinesSubcellular ProcessSymptomsTactileTechniquesTestingTouchTouch sensationTransgenic MiceVolatile Fatty AcidsWorkadenosine 3'5' monophosphatealimentary tractattenuateattenuatesbiological signal transductionbowelcAMPcell biologycohortcost estimatecost estimationcultured cell linedetection of nutrientdevelopmental diseasedevelopmental disorderdigestive canaldisorders of gut-brain interactiondysmotilitydysmotility syndromeelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsfluidgastrointestinalgastrointestinal functiongut to brain axisgut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalingimagingin vivoinnovateinnovationinnovativeliquidmechanicmechanicalmechanical cuemechanical forcemechanical signalmechanical stimulusmechanosensingmechanotransductionmotility disordermouse modelmucosal layer of the rectummurine modelnew diagnosticsnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnext generation diagnosticsnovelnovel diagnosticsnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetnutrient sensingorphan disorderpathwayperception of nutrientspharmacologicpreventpreventingproductivity losspublic health relevancereceptorrectal epitheliumrectal liningrectal mucosarectal mucosal tissueselective expressionselectively expressedsensorside effectsmall bowelsocial rolespastic colontactile sensation
Description preview
PROJECT SUMMARY/ABSTRACT
Disruptions in mechanosensation are commonly responsible for symptoms in diseases of gut-brain interaction
(DGBI), like irritable bowel syndrome (IBS), which affect ~15% of the US population. Therefore, my laboratory’s
long-term goal is to elucidate the cellular and molecular mechanisms of gastrointestinal (GI)…
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