grant
Mechanotransduction Control of CNS Myelin Sheath Length.
Organization UPSTATE MEDICAL UNIVERSITYLocation SYRACUSE, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressArchitectureAxonBiochemicalBody TissuesCNS Nervous SystemCalciumCaliberCell Communication and SignalingCell Culture TechniquesCell SignalingCellular MechanotransductionCellular biologyCentral Nervous SystemChemicalsControlled EnvironmentCuesDataDevelopmentDiameterDiseaseDisorderDisseminated SclerosisEngineering / ArchitectureFaceFiberFutureGeneralized GrowthGoalsGrowthImageIn vivo analysisIndividualInstructionIntracellular Communication and SignalingIon ChannelIonic ChannelsKinasesKnowledgeLengthLightMeasuresMechanical Signal TransductionMechanosensory TransductionMediatingMembrane ChannelsMethodsMiceMice MammalsModelingMolecularMultiple SclerosisMurineMusMyelinMyelin SheathNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNervous System DiseasesNervous System DisorderNervous System PhysiologyNeural CellNeuraxisNeurocyteNeurologicNeurologic DisordersNeurologic functionNeurologicalNeurological DisordersNeurological functionNeuronal TransmissionNeuronsOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPhosphotransferase GenePhosphotransferasesPhotoradiationPiezo 1Piezo 1 ion channelPiezo1ProcessPropertyProtein BiosynthesisProteinsProteomicsRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSignal TransductionSignal Transduction SystemsSignalingSliceSpeedSystemTestingTissue GrowthTissuesTranslatingTranslationsTransphosphorylasesVariantVariationWorkantagonismantagonistartificial environmentaxon signalingaxon-glial signalingaxonal signalingbiological signal transductioncell biologycell culturecell culturesdevelopmentaldisabilityfacesfacialglia signalingglial signalingimagingin vivoin vivo evaluationin vivo testinginnovateinnovationinnovativeinsular sclerosisknock-downknockdownlife spanlifespanmechanosensingmechanotransductionmyelinationnerve signalingnervous system functionneural networkneural signalingneurological diseaseneuronalneuronal signalingneurotransmissionontogenyoptogeneticsphospho-proteomicsphosphoproteomicsprotein synthesisre-myelinatere-myelinationremediationremyelinateremyelinationrepairrepairedresponserestorationsensorsocial rolethree dimensionaltooltranslation
Description preview
Project Summary
Loss and changes to central nervous system (CNS) myelin architecture are prevalent in neurological
conditions across the lifespan. Incomplete restoration of myelin sheaths, as seen in multiple sclerosis,
leads to disability. Our long-term goal is to identify developmental mechanisms controlling CNS myelin
formation essential to CNS…
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