grant
Mechanosensitive determinants of podocyte physiology
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Jul 2018Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253'-Amino-3'-deoxy-N,N-dimethyladenosine3'-amino-3'-deoxy-N,N-dimethyl-adenosineATP-protein phosphotransferaseActin FilamentsActinsAdhesion PlaquesAdverse ExperienceAdverse effectsAdverse eventAlbuminuriaArchitectureAssayAtomic Force MicroscopesAtomic Force MicroscopyAwardBCR-ABLBCR-ABL OncoproteinBCR-ABL Protein Tyrosine KinaseBCR/ABLBindingBioassayBiologic ModelsBiologicalBiological AssayBiological ModelsBiomechanicsBiophysicsBlood PlasmaCell BodyCell Communication and SignalingCell SignalingCell-Matrix Adherens JunctionsCellsCellular MatrixCharacteristicsChronic Granulocytic LeukemiaChronic Myelocytic LeukemiaChronic Myelogenous LeukemiaChronic Myeloid LeukemiaClinicalCommon Rat StrainsCrosslinkerCytoskeletal SystemCytoskeletonDasatinibDataDevelopmentDrosophila Homolog of Large Tumor Suppressor 1Drug InteractionsDrug KineticsDrug Side EffectsDrugsDysfunctionESKDESRDElectric Field MicroscopesEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEngineering / ArchitectureExhibitsExperimental ModelsFDA approvedFLK1Factor AnalysesFactor AnalysisFiltrationFiltration FractionationFocal AdhesionsFocal ContactsForce MicroscopyFunctional disorderFutureGlomerular diseaseHealthHumanImageImpairmentIn SituIn VitroInbred SHR RatsIndividualInjuryIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingKDR geneKidneyKidney DiseasesKidney GlomerulusKidney Urinary SystemKinase Family GeneKinasesLATS1LATS1 geneLateral Force MicroscopesLinkMachine LearningMagnetic Force MicroscopesMalpighian TuftMapsMeasurementMedicationMeta-AnalysisMethodsMicrofilamentsModel SystemModelingModern ManMolecularMolecular InteractionMorphologyMyofilamentsNephropathyNephrotoxicNetwork-basedOncologyOncology CancerPathway interactionsPatient MonitoringPatientsPharmaceutical PreparationsPharmacokineticsPhenotypePhosphotransferase GenePhosphotransferasesPhysiologyPhysiopathologyPlasmaPlasma SerumProtein KinaseProteinuriaProteomicsPublicationsPublishingPuromycin AminonucleosideRatRats MammalsRattusRecoveryRegulationRenal DiseaseRenal Glomerular Diseases and SyndromesRenal glomerular diseaseRenal glomerular disease or syndromeRenal glomerular disorderRenal glomerular syndromeReportingReproducibilityReticuloendothelial System, Serum, PlasmaRisk FactorsRoleSHR RatsScanning Force MicroscopyScanning Probe MicroscopesScanning Thermal MicroscopesScanning Tunneling MicroscopesScientific PublicationSeriesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpinal ColumnSpineSpontaneously Hypertensive RatsSystemSystems BiologyTestingTherapeuticToxic effectToxicitiesTransgenic MiceTransgenic OrganismsTranslatingTransphosphorylasesTreatment ProtocolsTreatment RegimenTreatment ScheduleTubularTubular formationVEGF ReceptorsVEGFRVEGFR-2VEGFR2VPF ReceptorVascular Endothelial Cell Growth Factor ReceptorVascular Endothelial Growth Factor Receptor 2Vascular Permeability Factor ReceptorVertebral columnVisceral Epithelial CellWorkbackbonebcr-abl Fusion Proteinsbiologicbiological signal transductionbiomechanicalbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesbuild resiliencebuild resiliencycrosslinkdata warehousedesigndesigningdevelop resiliencedevelop resiliencydevelopmentaldifferential expressiondifferentially expresseddrug/agentelastic imagingelasticity imagingelastographyenhance resilienceenhance resiliencyexperimentexperimental researchexperimental studyexperimentsfacilitate resilienceglomerular filtrationglomerular functionglomerular visceral epithelial cellglycogen synthase a kinasehydroxyalkyl protein kinaseiPSiPSCiPSCsimagingimprove resilienceimprove resiliencyimprovedin vivoin vivo Modelincrease resilienceincrease resiliencyinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibitorinjuriesintracellular skeletonkidney disorderkidney glomerulikidney toxicityleukemiamachine based learningmouse modelmultiomicsmultiple omicsmurine modelnephrotoxicitypanomicspathophysiologypathwaypharmacologicpharmacovigilancephenomephospho-proteomicsphosphoproteomicsphosphorylase b kinase kinasepodocytepromote resiliencepromote resiliencyprotein kinase inhibitorrenalrenal disorderrenal glomerulusresilienceresilience developmentresilientrisk mitigationscreeningscreeningssocial rolespontaneous hypertensive ratstandard of caretargeted agenttranscriptional differencestranscriptomicstransgenic
Description preview
PROJECT SUMMARY
Drug nephrotoxicity is often conflated with tubular injury; however, many nephrotoxic agents target the
glomerulus leading to proteinuric kidney disease. Mechanisms of drug-induced glomerular dysfunction are not
well understood. We have previously shown that altered cytoskeletal integrity of podocytes leads to changes in
their…
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