grant
Mechanobiology
Organization NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERINGLocation UNITED STATES
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAbscissionActinsActomyosinAdhesionsAffectAnisotropyAntigen-Presenting CellsApoptosisApoptosis PathwayArchitectureAreaAtlas of Cancer Mortality in the United StatesAtomic Force MicroscopyBehaviorBiochemicalBiologicalBiophysicsBiopolymersBody TissuesCD28CD28 geneCD3CD3 AntigensCD3 ComplexCD3 moleculeCancer BiologyCancer CauseCancer EtiologyCancer MapsCancer cell lineCancerousCancersCell BodyCell CoatCell Communication and SignalingCell ComponentsCell FunctionCell JunctionsCell LineCell PhysiologyCell ProcessCell SignalingCell StructureCell membraneCell surfaceCell-Extracellular MatrixCellLineCellsCellular FunctionCellular MatrixCellular MechanotransductionCellular PhysiologyCellular ProcessCellular StructuresCellular biologyCessation of lifeChemicalsComplexConfocal MicroscopyCuesCytoplasmic MembraneCytoskeletal GeneCytoskeletal ProteinsCytoskeletal SystemCytoskeletonDataDeathDepositDepositionDesmoplasticDesmoplastic ReactionDevelopmentDevelopmental BiologyDimensionsDissectionDrug resistanceDuctal Carcinoma of the PancreasECMERM proteinETV5 proteinEarly DiagnosisElasticityEngineeringEngineering / ArchitectureEts-related molecule PEA3-like proteinExcisionExhibitsExtirpationExtracellular MatrixExtracellular StructureF-ActinFilamentous ActinFluorescence Light MicroscopyFluorescence MicroscopyForce MicroscopyFutureGenerationsGlycansGlycocalyxGlycoproteinsGoalsHeterogeneityHyaluronic AcidHydrogelsImage AnalysesImage AnalysisImmuneImmune Cell ActivationImmune mediated therapyImmunesImmunologically Directed TherapyImmunotherapyIn VitroIndividualInflammationIntegrinsIntegrins Extracellular MatrixIntercellular JunctionsIntracellular Communication and SignalingKineticsKnowledgeLengthLiquid substanceMHC ReceptorMaintenanceMajor Histocompatibility Complex ReceptorMalignant CellMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMapsMathMath ModelsMathematicsMeasuresMechanical Signal TransductionMechanicsMechanosensory TransductionMembraneMetabolic GlycosylationMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMicro-tubuleMicroscopyMicrotubulesMicrovilliMicrovillusModificationModulusMolecularMucinsMucus GlycoproteinMyosin IIMyosin Type IIN-Acetylneuraminic AcidsNIBIBNational Institute of Biomedical Imaging and BioengineeringNatureNeoplasm MetastasisOKT3 antigenOpticsPancreasPancreas CancerPancreas Duct-Cell CarcinomaPancreas Ductal AdenocarcinomaPancreaticPancreatic CancerPancreatic Duct Cell CarcinomaPancreatic Ductal AdenocarcinomaPancreatic Ductal CarcinomaPathologyPathway interactionsPatientsPeptidesPeripheralPhysicsPhysiologicPhysiologicalPlasma MembranePlayPolysaccharidesPositionPositioning AttributePostdocPostdoctoral FellowProcessProductionProgrammed Cell DeathProliferatingPropertyRegulationRegulatory ProteinRemovalResearch AssociateResistanceResolutionRoleSamplingScanning Electron MicroscopyScanning Force MicroscopySecondary NeoplasmSecondary TumorSialic AcidsSignal TransductionSignal Transduction SystemsSignalingSiliconesSolidSolid NeoplasmSolid TumorStrains Cell LinesStressStructureSubcellular ProcessSurgical RemovalSurvey InstrumentSurveysSurvival RateT cell responseT-Cell ActivationT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT3 AntigensT3 ComplexT3 moleculeT44TM-MKRTechniquesTherapeuticThickThicknessTissuesTractionTraction Force MicroscopyTranslatingTransmissionTumor MarkersUV laboratory microscopeUltraviolet MicroscopesUnited StatesViscosityVisualizationWorkaccessory cellactivate T cellsattenuationbiologicbiological signal transductionbiophysical approachesbiophysical equipmentbiophysical foundationbiophysical methodologybiophysical methodsbiophysical principlesbiophysical sciencesbiophysical techniquesbiophysical toolscancer cellcancer metastasiscancer progressioncantilevercell biologycellular microvilluschemotherapycomplex biological systemscultured cell linecytotoxicdensitydevelopmentaldrug resistantearly detectionengineered T cellsezrinfluidfluidityfluorescence microscopefluorescence/UV microscopefluorescent microscopegenetic regulatory proteingenetically engineered T-cellsglycosylationimage evaluationimage interpretationimmune activationimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunological synapseimmunological synapse formationinsightintracellular skeletonlaboratory fluorescence light microscopeliquidmacromolecular assemblymalignancymaterials sciencemathematic modelmathematical modelmathematical modelingmechanicmechanicalmechanical forcemechanical propertiesmechanosensingmechanotransductionmembrane structuremigrationmolecular mechanicsmultidisciplinarynano mechanicsnano meter scalenano meter sizednanomechanicsnanometer scalenanometer sizednanoscaleneoplasm progressionneoplasm/cancerneoplastic progressionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynon-muscle myosinnonmuscle myosinnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetopticaloverexpressoverexpressionpancreatic cancer cellspancreatic malignancypancreatic tumor cellspathwayphosphoprotein p81plasmalemmapost-docpost-doctoralpost-doctoral traineepressurepreventpreventingreceptor bindingreceptor boundregulatory gene productresearch associatesresectionresistance to Drugresistantresistant to Drugresolutionsresponseself organizationsialylationsocial rolespatial and temporalspatial temporalspatiotemporalsuper high resolutionsuperresolutionthree dimensionalthymus derived lymphocytetooltransgenic T- cellstransmission processtumor biomarkertumor cell metastasistumor progressiontumor specific biomarkerultra high resolutionviscoelasticity
Description preview
The NIBIB’s Section on Mechanobiology focuses on developing advanced atomic force microscopy (AFM) techniques to assess the micro- and nano-scale mechanical properties of cells and tissues. AFM involves probing samples using a micron-sized cantilever, with or without an indenter, to non-invasively measure material properties in complex biological…
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