grant
Mechanistic structure-function relationships for paraspinal muscle fat infiltration in chronic low back pain patients
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Jun 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAffectAgeAnatomic AbnormalityAnatomical AbnormalityAstronautsAtrophicAtrophyBiomechanicsBiometricsBiometryBiopsyBiostatisticsChronic low back painComplexCosmonautsDataDeformityDisablingDysfunctionElectromyographyExposure toExpression SignatureFatigueFatsFatty acid glycerol estersFibrosisFunctional disorderFutureGene Expression ProfileGenesHealthHerniated DiscInfiltrationInflammatoryInflammatory ResponseInjectionsIntervertebral Disc Degenerative DiseaseIntervertebral Disc Degenerative DisorderIntervertebral DiskIntervertebral disc structureLack of EnergyLongitudinal StudiesMR ImagingMR TomographyMRIMRIsMachine LearningMagnetic Resonance ImagingMapsMeasurementMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMolecularMovementMuscleMuscle DevelopmentMuscle TissueMuscular DevelopmentNMR ImagingNMR TomographyNetwork AnalysisNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresPain ControlPain TherapyPain managementPathologyPathway AnalysisPatient SelectionPatientsPatternPhenotypePhysiopathologyPositionPositioning AttributePostureProceduresProgenitor CellsProlapsed DiskRiskRoleRotationSlipped DiskSpace FlightSpaceflightSpatial DistributionSpinalSpinal ColumnSpineStructureStructure-Activity RelationshipSurfaceSurgicalSurgical InterventionsSurgical ProcedureSymptomsSystemTestingTherapeuticTimeTissue SampleUncertaintyVertebral columnWalkingWorkZeugmatographyagesbackbonebiomechanicalbody movementbody sensorbody worn sensorchemical structure functionclinical imagingclinical relevanceclinically relevantdegenerated intervertebral discdegenerative disc diseasedisabilitydisc degenerationdoubteffective therapyeffective treatmentfunctional outcomesgene expression patterngene expression signatureglobal gene expressionglobal transcription profileimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedimproved outcomeintervertebral disk degenerationkinematic modelkinematicslicit opioidlong-term studylongitudinal outcome studiesmachine based learningmotor controlmuscle degenerationmuscle regenerationmuscularneuromuscularnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyopiate medicationopioid medicationpain interventionpain patientpain symptompain treatmentpainful symptompathophysiologyprescribed opiateprescribed opioidprescription opiateprescription opioidpreventpreventingrehab strategyrehabilitation strategyresponseruptured disksocial rolestem cellsstructure function relationshipsurgerythree dimensionaltooltranscriptional profiletranscriptional signaturetranscriptomewearable biosensorwearable sensorwearable sensor technology
Description preview
PROJECT SUMMARY
Chronic low back pain (cLBP) is the world's leading debilitating condition and the most common reason for
opioid prescription in the US. While axial cLBP is commonly considered non-specific and multifactorial, it is
often suspected a dysfunction of the spinal stabilization system that includes the intervertebral disc (IVD) and…
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