grant
Mechanistic intersection between placental vascular and newborn neuronal development
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 9 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20260-11 years oldAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdventitial CellAffectAfricaAngiogenesis FactorAngiogenic FactorAnti-Retroviral AgentsAttentionAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBeta Cadherin-Associated ProteinBeta-1 CateninBirthBlood - brain barrier anatomyBlood VesselsBlood-Brain BarrierBody TissuesBrainBrain Nervous SystemBrain VascularCUL-2CaringCell BodyCell Communication and SignalingCell SignalingCellsCells Placenta-TissueChildChild HealthChild YouthChildren (0-21)Computer AnalysisCountryDevelopmentDysfunctionEncephalonEndothelial CellsEndotheliumEnrollmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFetal GrowthFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFormalinFunctional disorderGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenetic TranscriptionGestationGoalsGrowthHIVHIV InfectionsHIV individualsHIV infected individualsHIV infected personsHIV peopleHIV positive individualsHIV positive peopleHIV viral infectionHIV virus infectionHIV-1 infectionHealthHemato-Encephalic BarrierHumanHuman Immunodeficiency VirusesHypoxiaHypoxicImage AnalysesImage AnalysisImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologyIn Situ HybridizationInfection by HIV-1Infection from HIV-1Infection of HIV-1Intracellular Communication and SignalingInvestigatorsLAV-HTLV-IIILEF-1 proteinLaboratoriesLeadLifeLinkLocationLymphadenopathy-Associated VirusMacrophageMaternal and Child HealthMesenchymasMesenchymeMetabolicMethodsMiceMice MammalsMiscarriageModern ManMolecular TargetMothersMurineMusMφNeural DevelopmentNeurologicNeurologicalNormal PlacentomaOutcomeOxygen DeficiencyPLWHPRO2286PWHParaffin EmbeddingParturitionPathologyPathway interactionsPb elementPericapillary CellPericytesPerinatalPeripartumPerivascular CellPhysiopathologyPlacentaPlacenta DiseasesPlacenta DisordersPlacenta Embryonic TissuePlacental DevelopmentPlacental DiseasesPlacental ProteinsPlacentationPlacentomePlayPopulationPregnancyPregnancy ProteinsPregnant WomenPremature BirthPrematurely deliveringPreterm BirthProteinsProteomicsRNA ExpressionReporterResearchResearch PersonnelResearchersRiskRoleRouget CellsSamplingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSourceSpontaneous abortionStaining methodStainsTissue GrowthTissue ModelTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesVillusVirus-HIVWestern BlottingWestern ImmunoblottingWorkadverse birth outcomesanalyze gene expressionangiogenesisanti-retroviralantiretroviral therapyantiretroviral treatmentbefore conceptionbeta catbeta cateninbeta-D-Galactosidasebeta-D-Galactoside galactohydrolasebeta-Galactosidasebiobankbiological signal transductionbiorepositorybloodbrain barrierbrain tissuecerebral vascularcerebro-vascularcerebrovascularcognitive abilitycohortcomputational analysescomputational analysiscomputer analysesdesigndesigningdevelopmentaldrivingefavirenzenrollepigeneticallyexpectant motherexpectant womenexpecting motherexpecting womenfetalflow cytophotometrygene expression analysisgene expression assayheavy metal Pbheavy metal leadhigh riskhuman immunodeficiency virus infectionimage evaluationimage interpretationimpaired brain developmentimprovedin situ Hybridization Geneticsin situ Hybridization Staining Methodin uteroin vivoindividuals infected with HIVindividuals who are pregnantindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusinnovateinnovationinnovativeinterestintra-uterine growthintrauterine growthkidslac Z Proteinlong-term memorylymphoid enhancer-binding factor 1mouse modelmultidisciplinarymurine modelneural inflammationneurodevelopmentneuroinflammationneuroinflammatoryneuron developmentneuronal developmentneuropsychiatric diseaseneuropsychiatric disordernewborn neuronnoveloffspringontogenypathophysiologypathwaypeerpeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople who are pregnantpeople with HIVpeople with human immunodeficiency virusplacental disorderspreconceptionpregnant femalespregnant motherspregnant peoplepregnant populationspremature childbirthpremature deliverypreterm deliveryprior to conceptionprocessing speedprotein blottingprotein expressionsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsthose who are pregnanttranscription factortranscriptional profilingtranscriptomicstrophoblastvascularvascular abnormalityvasculogenesiswomen who are pregnantyoungsterβ-D-Galactosidaseβ-D-Galactoside galactohydrolaseβ-Galactosidaseβ-catenin
Description preview
PROJECT SUMMARY
More than one million children who are HIV-exposed but uninfected (HEU) are born to pregnant people with HIV
(PPHIV) every year. HEU children have poorer early-life outcomes than their HIV-unexposed peers, including
an increased risk of adverse neurodevelopmental outcomes. The pathophysiology of HEU neurodevelopmental
outcomes is…
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