grant
Mechanistic Insights Underlying LZTR1-Related Schwannomatosis
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 12 Jan 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY2026Adaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAddressAffectAllelesAllelic LossAllelomorphsAncient NeurilemmomaAncient SchwannomaAnimal ModelAnimal Models and Related StudiesAppearanceAssayAxonBAF47BAF47 GeneBindingBioassayBiochemicalBiological AssayBiological FunctionBiological ProcessCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell LineCell NucleusCell PhysiologyCell ProcessCell SignalingCell modelCellLineCellsCellular AssayCellular ExpansionCellular FunctionCellular GrowthCellular PhysiologyCellular ProcessCellular modelClinicalClinical TrialsComplexCullin Homolog 3DNA mutationDataDefectDegenerated NeurilemmomaDegenerated SchwannomaDevelopmentDiseaseDisorderDrug TherapyDysfunctionEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpistasisEpistatic DeviationExhibitsExperimental ModelsExperimental TherapiesExtracellular Signal-Regulated Kinase GeneFunctional disorderGEM modelGEMM modelGTP PhosphohydrolasesGTPasesGene ExpressionGene TranscriptionGeneticGenetic ChangeGenetic EpistasisGenetic TranscriptionGenetic defectGenetic mutationGenetically Engineered MouseGoalsGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHeterograftHeterologous TransplantationHumanINI1INI1 GeneIndividualInteraction DeviationIntracellular Communication and SignalingInvestigational TherapiesInvestigational TreatmentsKnock-outKnockoutKnowledgeLaboratoriesLesionLinkLocationLoss of HeterozygosityMAP Kinase GeneMAPKMediatingMerlinMiceMice MammalsMitogen-Activated Protein Kinase GeneModelingModern ManMoesin-Ezrin-Radixin-Like ProteinMolecularMolecular InteractionMorbidityMurineMusMutationNF2NF2 Gene ProductNF2 geneNatureNerveNeurilemma CellNeurilemmal CellNeurilemmomaNeurilemmomatosisNeurilemomaNeurinomaNeurofibromatosis 2 Gene ProductNeurofibromatosis 2 GenesNeurofibromatosis Type 2 ProteinNeurofibromin 2NucleusOrphan DiseasePainPainfulPathogenesisPathway interactionsPatientsPeripheral Nerve SchwannomaPharmacological TreatmentPharmacotherapyPhenotypePhysiopathologyPost-Transcriptional Gene SilencingPre-Clinical ModelPreclinical ModelsProceduresProcessPropertyProteinsProteomicsRNA ExpressionRNA InterferenceRNA SilencingRNAiRadiation therapyRadiotherapeuticsRadiotherapyRare DiseasesRare DisorderRecurrenceRecurrentRodentRodentiaRodents MammalsSMARCB1SMARCB1 geneSNF5SNF5 GeneSNF5L1SNF5L1 GeneSWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 GeneSchwann CellsSchwannomaSchwannomatosisSchwannomerlinSchwannominSchwannomin ProteinSequence-Specific Posttranscriptional Gene SilencingSeriesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesSubcellular ProcessTechnologyTestingTherapeuticTherapeutic InterventionTranscriptionTranslatingTumor CellUbiquitilationUbiquitin Ligase Component GeneUbiquitin Ligase GeneUbiquitinationUbiquitinoylationWorkXenograftXenograft ModelXenograft procedureXenotransplantationadapter proteinallotransplantallotransplantationanti-tumor effectantitumor effectaxon damageaxon injuryaxonal damageaxonal injurybiological signal transductioncell assaycell dedifferentiationcell growthcell immortalizationcellular differentiationclinical developmentcullin-3cultured cell linedevelopmentaldisease modeldisorder modeldrug candidatedrug interventiondrug treatmenteffective therapyeffective treatmentepigeneticallyepistatic interactionepistatic relationshipexperimental therapeutic agentsexperimental therapeuticsgene x gene interactiongenetic approachgenetic epistasesgenetic etiologygenetic mechanism of diseasegenetic strategygenetically engineered mouse modelgenetically engineered murine modelgenome mutationguanosinetriphosphatasehSNF5/INI1 GeneiPSiPSCiPSCsin vivoinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibitorinsightintervention therapymodel of animalmouse modelmurine modelmyelinationneoplastic cellnerve injuryneural injuryneurogeneticsneurosurgerynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynf 2 Genesnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachorphan disorderpathophysiologypathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingprogenitorradiation treatmentrepairrepairedresponsesciatic nervetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic agent developmenttherapeutic developmenttherapeutic evaluationtherapeutic testingtooltranscriptomicstreatment with radiationtumorubiquinationubiquitin conjugationubiquitin ligasexeno-transplantxeno-transplantationxenograft transplant modelxenotransplant model
Description preview
SUMMARY
Schwannomatosis is a rare neurogenetic disorder characterized by the development of Schwann cell tumors,
known as schwannomas, which grow along different nerves, causing significant morbidity and pain. There are
at least three different types of this condition, based on their genetic etiology and clinical presentation: NF2,
LZTR1, and…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click