grant
Mechanistic insights into translesion synthesis-dependent genome instability
Organization UNIVERSITY OF VERMONT & ST AGRIC COLLEGELocation BURLINGTON, UNITED STATESPosted 15 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AutophagocytosisBiologicalBlack BoxBypassCancersCell DeathCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCommunicable DiseasesDNADNA DamageDNA InjuryDNA ReplicationDNA SynthesisDNA biosynthesisDNA mutationDataDegenerative Neurologic DisordersDeoxyribonucleic AcidDimensionsDisease ProgressionEnzyme GeneEnzymesExerciseGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGenome ComponentsGenome InstabilityGenomic InstabilityGoalsHuman GenomeInfectious DiseasesInfectious DisorderIntermediary MetabolismLaboratoriesM PhaseMalignant NeoplasmsMalignant TumorMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMitosisMitosis StageMitoticModelingModificationMolecularMutagenesisMutagenesis Molecular BiologyMutationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsOnset of illnessOther GeneticsPathway interactionsPolymeraseProcessProteinsPublicationsRoleScientific PublicationSubcellular ProcessTranslatingWorkautophagybiologicdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdisease controldisease onsetdisorder controldisorder onsetgenome mutationhuman diseasehuman whole genomeinsightmalignancynecrocytosisneoplasm/cancerneurodegenerative illnessnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwayreplication stressresponsesenescencesenescentsocial roletool
Description preview
Genome instability, characterized by increased formation of DNA mutations and other genetic
modifications, is a causative factor in multiple human diseases including cancer, infectious
diseases, and neurodegenerative disorders. The translesion synthesis (TLS) pathway, by means
of its low fidelity polymerases, causes mutagenesis by bypassing DNA…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click