grant
Mechanistic characterization of vaginal microbiome-metabolome associations and metabolite-mediated host inflammation
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 17 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20261,4-Butanediamine1,4-Diaminobutane1,5-PentanediamineAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAffectAfrica South of the SaharaAfricanAfrican FemalesAfrican WomenAminesAnabolismAnatomic SitesAnatomic structuresAnatomyBacteriaBacterial PhysiologyBacterial VaginitisBacterial VaginosisBacteriologyBiochemicalBiogenic AminesBioinformaticsBiological MarkersBiologyBody TissuesCadaverineCancersCell Growth in NumberCell MultiplicationCell ProliferationCellular Metabolic ProcessCellular ProliferationCervical CancerCervix CancerChemicalsChemistryClinicalClinical MarkersCollaborationsCommunicable DiseasesCommunitiesDataDevelopment PlansDiseaseDisorderDisproportionate number of femalesDisproportionate number of womenDisproportionately affects femalesDisproportionately affects womenDisproportionately impacts femalesDisproportionately impacts womenDisproportionately in femalesDisproportionately in womenDysfunctionEnvironmentEnzymatic BiochemistryEnzyme AntagonistEnzyme GeneEnzyme InhibitorEnzyme Inhibitor AgentEnzyme Inhibitor DrugsEnzymesEnzymologyFunctional MetagenomicsFunctional disorderGeneral HospitalsGenomicsGoalsHIVHIV riskHealthHuman Immunodeficiency VirusesIF-5AImidazoleImmune responseImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologyImmunomodulationIn VitroInfectious DiseasesInfectious DisorderInflammationInflammatoryInflammatory ResponseInvestigatorsKnowledgeLAV-HTLV-IIILactobacillusLinkLymphadenopathy-Associated VirusMalignant Cervical NeoplasmMalignant Cervical TumorMalignant Neoplasm of the CervixMalignant NeoplasmsMalignant TumorMalignant Tumor of the CervixMalignant Tumor of the Cervix UteriMalignant Uterine Cervix NeoplasmMalignant Uterine Cervix TumorMalignant neoplasm of cervix uteriMassachusettsMeasuresMediatingMediatorMedicineMentorsMetabolicMetagenomicsMethodsMicrobial BiofilmsMucosaMucosal InflammationMucosal TissueMucositisMucous MembraneNonspecific VaginitisOlfactionOutcomePathogenesisPathogenicityPathway interactionsPentamethylenediaminePhysiciansPhysiopathologyPopulationPremature BirthPrematurely deliveringPreterm BirthPrevalenceProductionPropionatesPutrescineReproducibilityResearchResearch PersonnelResearchersRoleScientistSiteSmellSmell PerceptionSourceSouth AfricanSub-Saharan AfricaSubsaharan AfricaSymptomsTestingTetramethylenediamineTherapeuticTissuesTrainingUniversitiesUterine Cervix CancerVaginaVaginal DiseasesVaginal DisorderValidationVirus-HIVWomanaminebacterial communitybio-markersbiofilmbiologic markerbiomarkerbiosynthesiscandidate biomarkercandidate identificationcandidate markercareercareer developmentcell metabolismcellular metabaolismclinical biomarkersclinically useful biomarkerscohortcytokinediagnostic criteriaeIF-4DeIF-5AeIF5A proteinenzyme activityeukaryotic initiation factor-4Dexperienceexperimentexperimental researchexperimental studyexperimentsfemale biasfemale predominancefemale preponderancegenital tracthigh level productionhigh scale productionhigh volume manufacturinghigh volume productionhost responseimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponsein vivoinhibitorinnovateinnovationinnovativeinstructorinterestmalignancymedical collegemedical schoolsmetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmetagenomemetatranscriptomicsmicrobialmicrobial consortiamicrobial floramicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremicrobiotamicrofloramultidisciplinarymultiomicsmultiple omicsmultispecies consortianeoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnon-specific vaginitisnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachodor perceptionolfactory perceptionpanomicspathophysiologypathwaypharmacologicpotential biological markerpotential biomarkerpredominance in femalespredominance in womenpremature childbirthpremature deliverypreterm deliverypreventpreventingreproductive outcomereproductive tractschool of medicineskillssocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranslation factorvagina disordervaginal biomevaginal floravaginal fluidvaginal microbial communityvaginal microbiomevaginal microbiotavaginal microfloravalidationswomen's predominancewomen's preponderance
Description preview
Project Summary/Abstract The vaginal microbiome is associated with important health
outcomes, including bacterial vaginosis (BV), preterm birth, HIV risk, and cervical cancer, but mechanisms for these associations are unclear and current microbiome-directed therapies have low efficacy. Metabolome alterations including high-level production of…
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