grant
Mechanisms that Regulate Antibody Class Switch Recombination and Somatic Hypermutation
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 15 Dec 2008Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026AddressAllelesAllelism TestAllelomorphsAntibodiesAntigensAssayAutoantigensAutologous AntigensB blood cellsB cellB cell repertoireB cellsB-Cell ActivationB-CellsB-LymphocytesB-cellBindingBioassayBiologic ModelsBiological AssayBiological ModelsBlastosphereCell BodyCell CycleCell Division CycleCell LineCell LineageCellLineCellsChromatinChromatin LoopChromatin Loop DomainsChronicClass SwitchingClass SwitchingsCommentCommentaryComplementation TestComplexConstant RegionDNA LoopDSS colitisDSS modelDSS mouse modelDSS-induced acute colitisDSS-induced colitisDevelopmentDiseaseDisorderDownstream EnhancerES cellEditorial CommentElementsEngineeringEnhancersExonsFirst Gap PhaseFrequenciesG1 PhaseG1 periodGRO-seqGROseqGap Phase 1Gene TranscriptionGenerationsGenetic Complementation TestGenetic TranscriptionGenomic SegmentGerm LinesGerminal CenterGoalsGrantGuide RNAHumanIg Constant RegionIg Somatic HypermutationImageImmunoglobulin Class SwitchingImmunoglobulin Class SwitchingsImmunoglobulin Constant RegionImmunoglobulin Isotype-Switch RecombinationImmunoglobulin Somatic HypermutationImmunoglobulin Switch RecombinationImmunoglobulin V(D)J RearrangementInstructionIntestinalIntestinesIsotype SwitchingIsotype SwitchingsKnock-inLabelLocationMapsMediatingMiceMice MammalsModel SystemModelingModern ManMolecular InteractionMurineMusPETPET ScanPET imagingPETSCANPETTPatternPeyer's PatchesPhysiologicPhysiologicalPhysiologyPlayPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredispositionPreimplantation EmbryoProbabilityProductivityProgress ReportsPublicationsPublished CommentRNA ExpressionRad.-PETRecurrenceRecurrentRegulationRepetitive ElementRepetitive RegionsRepetitive SequenceReportingResearchRoleScientific PublicationSelf-AntigensSiteStrains Cell LinesStructure of germinal center of lymph nodeStudy modelsSusceptibilitySwitch RecombinationSystemTestingTextbooksTrans TestTranscriptionV(D)J RearrangementV(D)J RecombinationVDJ rearrangementVDJ recombinationViewpointWorkactivated B cellsblastocystblastulabowelcohesincolitis-induced dysbiosiscomplementation analysiscomplementation approachcultured cell linedevelopmentaldextran sulfate sodium colitisdextran sulfate sodium induced colitisdextran sulfate sodium modeldextran sulfate sodium mouse modeldietaryembryo derived stem cellembryonal stem cellsembryonic progenitorembryonic stem cellgRNAgenome segmentgenomic regionglobal run on sequencingglobal run on transcription sequencingimagingimmunogenin vivoin vivo Modelinsightknockinmicrobialmicrobiomemicrobiota compositionmouse modelmurine modelnew technologynewsnovel technologiespandemicpandemic diseasepositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-implantation embryoprotein complexrepairrepairedresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesomatic hypermutationstem cell of embryonic origin
Description preview
Project Summary/Abstract of Research Plans for the Extension Period
The first two specific aims of this R37 grant were to test our hypothesis that cohesin-mediated loop
extrusion plays a key role in lgH class switch recombination (CSR) and lg variable region exon somatic
hypermutation (SHM). A third aim was to test our hypothesis that Peyer's…
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