grant
Mechanisms that establish a functional stem cell niche during organogenesis
Organization EAST CAROLINA UNIVERSITYLocation GREENVILLE, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY202621+ years oldAblationAdultAdult HumanAgingAnteriorArchitectureAssayAutoregulationBasal Transcription FactorBasal transcription factor genesBehaviorBioassayBiologicalBiological AssayBody TissuesCell BodyCell Communication and SignalingCell SignalingCellsCellular MatrixCommunicationCuesCytoskeletal SystemCytoskeletonDataDevelopmentDrosophilaDrosophila genusEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEngineering / ArchitectureF-ActinFilamentous ActinFundingGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic ModelsGonadal structureHomeostasisImageInjuryIntracellular Communication and SignalingLaser ElectromagneticLaser RadiationLasersLocationMaintenanceMechanicsMethodsModelingMorphogenesisMorphologyMovementMuscleMuscle TissueNatural regenerationOrganogenesisOrthologOrthologous GenePhysiological HomeostasisPopulationPositionPositioning AttributeProgenitor CellsProtocolProtocols documentationRegenerationSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedSystemTesticlesTestingTestisTissuesTranscription Factor Proto-OncogeneTranscription factor genesVisceralVisualizationWorkadulthoodbiologicbiological signal transductionbody movementcell behaviorcellular behaviordevelopmentaldriving forcefruit flygonadgonadsimage-based methodimagingimaging in vivoimaging methodimaging modalityin vivoin vivo imaginginjuriesintracellular skeletonisletmechanicmechanicalmigrationmorphogenetic processmuscularnoveloptogeneticsprogenitor cell nicheprogenitor nicheregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresponsestem and progenitor cell nichestem cell nichestem cellstissue regenerationtissue regrowthtissue renewaltissue specific regenerationtranscription factorunpublished works
Description preview
Project Summary/Abstract:
Stem cells are required for tissue homeostasis and regeneration. Accomplishing these tasks requires intimate
association with a niche, a cellular microenvironment that forms in a specialized tissue location with precise
morphology to enable communication with stem cells. Niches are formed by cells that must be specified…
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