grant
Mechanisms supporting selective affiliation between peers
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 6 May 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025ASDAccelerationAffectAggressionAggressive behaviorAutismAutistic DisorderBehaviorBeuren syndromeBindingBrain regionBuffersCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell Communication and SignalingCell SignalingCellular Immune FunctionCharacteristicsClustered Regularly Interspaced Short Palindromic Repeats interferenceCognitive DiscriminationComplexDiscriminationEarly Infantile AutismElfin Facies SyndromeExhibitsFamiliarityFamily memberFanconi Schlesinger syndromeFanconi-Schlesinger syndromeFoundationsFriendsFriendshipsGoalsHealthHeart VascularHousingHumanImpairmentIndividualIndividual DifferencesInfantile AutismInfusionInfusion proceduresIntracellular Communication and SignalingKanner's SyndromeKnock-outKnockoutLaboratoriesLateralLength of LifeLongevityMaintenanceMeasuresMediatingMethodsMicrotusModern ManMolecular InteractionMoodsMotivationNeuropeptidesNucleus AccumbensOcytocinOxytocinOxytocin ReceptorPair BondPersonal SatisfactionPlayReceptor ProteinReceptor SignalingRecombinant OxytocinRelationship-BuildingResearchRodentRodentiaRodents MammalsRoleSame-sexSeasonsShapesSignal TransductionSignal Transduction SystemsSignalingSocial BehaviorSocial EnvironmentSocial InteractionSpecificityStressStressful EventTestingTimeTranslatingVoleWilliams Barratt syndromeWilliams Contiguous Gene SyndromeWilliams SyndromeWilliams-Barratt syndromeWilliams-Beuren SyndromeWorkantagonismantagonistanti socialantisocialantisocial behaviorautism spectral disorderautism spectrum disorderautistic spectrum disorderbiological signal transductioncirculatory systemelfin-facies hypercalcemia syndromefield mousegene manipulationgenetic manipulationgenetically manipulategenetically perturbhypercalcemia-peculiar facies-supravalvular aortic stenosis syndromehypercalcemia/Williams-Beuren syndromeidiopathic hypercalcemia-supravalvular aortic stenosis syndromeimmune functioninfusionsmental retardation-typical facies-aortic stenosis syndromemodel organismmortalityneuralnovelpeerpeer supportprairie volepreferencereceptorrepressing CRISPR-dCas9 systemreproductivesexsocialsocial attachmentsocial bondingsocial climatesocial contextsocial factorssocial neurosciencesocial relationshipssocial rolesocial structuralsocial structuresocio-structuralsociobehaviorsociobehavioralsocioenvironmentsocioenvironmentalsociostructuralstressful experiencestressful life eventstressful life experiencewell-beingwellbeing
Description preview
PROJECT SUMMARY/ABSTRACT
Humans form social attachments and develop friendships throughout our lifetimes, with fundamental
consequences for wellbeing. Decades of research have established the importance of the neuropeptide
oxytocin (OT) for social bond formation with reproductive partners. In contrast, very little is known about the
mechanisms…
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