grant
Mechanisms, Structures and Engineering of Flavonoid-producing Dioxygenase Enzymes
Organization CALIFORNIA STATE UNIV SAN BERNARDINOLocation SAN BERNARDINO, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20252-Phenyl-Benzopyrans2-Phenyl-Chromenes2-ketoglutarate2-oxoglutarate3-D3-Dimensional3DActive SitesAffectAffinityAnabolismAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAssayBBB crossingBP reductionBindingBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBlood PlasmaCaliforniaCellular Immune FunctionCerebrovascular CirculationChemicalsCognitiveDataDevelopmentDietary FlavonoidDimerizationDioxygenasesDiseaseDisease OutcomeDisorderDisputesEngineeringEnvironmentEnzyme GeneEnzymesFaceFamilyFe elementFlavanonesFlavonoidsFutureGI microbiomeGI microbiotaGastrointestinal microbiotaGoalsH+ elementHealthHealth BenefitHumanHydrogen IonsHydroxylasesIronIsotope LabelingKnowledgeLDLLDL LipoproteinsLow-Density LipoproteinsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMeasuresMedicalMentorsMetabolicMethodsMixed Function OxidasesMixed Function OxygenasesModelingModern ManMolecular InteractionMolecular Sieve ChromatographyMonooxygenasesNatural ProductsOutcomePathway interactionsPlantsPlasmaPlasma SerumProduct LabelingProtein DimerizationProteinsProtonsPublic HealthQuercetinReactionResearchResolutionReticuloendothelial System, Serum, PlasmaRoentgen RaysRoleScanningSingle Crystal DiffractionSite-Directed MutagenesisSite-Specific MutagenesisSize Exclusion ChromatographyStable Isotope LabelingStructureStudentsTargeted DNA ModificationTargeted ModificationTechniquesTestingUniversitiesVariantVariationWorkX Ray CrystallographiesX-RadiationX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray RadiationX-Ray/Neutron CrystallographyX-rayXrayXray Crystallographyalpha ketoglutarateanalytical ultracentrifugationbasebasesbeta-Lipoproteinsbiosynthesisblood flow in brainblood pressure reductionblood-brain barrier crossingbloodbrain barrier crossingbrain blood circulationbrain blood flowcerebral blood flowcerebral circulationcerebrocirculationcerebrovascular blood flowdevelopmentaldigestive tract microbiomedihydroquercetindimerenteric microbial communityenteric microbiomeenteric microbiotaenzyme mechanismenzyme structureexperiencefacesfacialgastrointestinal microbial floragastrointestinal microbiomegut communitygut dysbiosisgut floragut healthgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehepatoprotectionhepatoprotectiveimmune functioninnovateinnovationinnovativeintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloralower BPlower blood pressurelowers blood pressuremicrobiomemutantnaturally occurring productnovelpathwaypreventpreventingreduce BPreduce blood pressurereduction in BPreduction in blood pressureresearch studyresolutionssocial rolestudent researchstudent-led researchtaxifolinthree dimensionaltoolundergradundergraduateundergraduate studentα-ketoglutarateα-oxoglutarateαKG
Description preview
ABSTRACT
The overall objective of this research is to fill in the gaps that exist in our structural and mechanistic
understandings of alpha ketoglutarate-dependent dioxygenases, a medically important family of enzymes that
perform a broad repertoire of biochemical transformations. The flavonoid biosynthetic pathway is dependent
upon Flavanone…
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