grant
Mechanisms regulating telomere length, protection and replication
NIHUS FederalResearch GrantFY2026AddressAgingAssayBinding ProteinsBioassayBiochemicalBiological AssayCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancersCell LineCellLineChromosomesComplexDNADNA DamageDNA Double Strand BreakDNA InjuryDNA PolymerasesDNA ReplicationDNA SynthesisDNA biosynthesisDNA polymerase alpha-primaseDNA polymerase α-primaseDNA replication forkDNA-Dependent DNA PolymerasesDNA-Directed DNA PolymeraseDeoxyribonucleic AcidFutureGenomeGenome StabilityGenomic StabilityGenomicsHumanInvadedKnowledgeLengthLigand Binding ProteinLigand Binding Protein GeneMaintenanceMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMetaphaseMiceMice MammalsMitotic MetaphaseModern ManMurineMusProtein BindingProteinsRepressionResearchSpeedStrains Cell LinesSystemTechniquesTelomeraseTelomere Length MaintenanceTestingVisualizationbound proteinclustered regularly interspaced short palindromic repeats screencultured cell linegenetic approachgenetic strategygenome scalegenome-widegenomewidehuman diseaseinnovateinnovationinnovativeinsightinventionmalignancymouse modelmurine modelneoplasm/cancernovelpreventpreventingprotein complexprotein purificationrecruitrepairrepairedreplication forkreplication stressresponsesingle moleculestemtelomere
Description preview
PROJECT SUMMARY
Telomeres are TTAGGG repetitive DNA-protein complexes at chromosome ends required to solve three
significant problems critical for the maintenance of genome stability. The “end replication problem” is due to
the inability of DNA polymerase to completely copy the lagging strand of chromosome ends, necessitating
telomerase to…
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