grant
Mechanisms regulating fetal membrane and neutrophil responses to infection
NIHUS FederalResearch GrantFY20253-10CAMCF-IAcetylmuramyl-Alanyl-IsoglutamineAgonistAllopurinolAmnionitidesBacteriaBacterial InfectionsBlood NeutrophilBlood Polymorphonuclear NeutrophilCXCL8Cell BodyCell Communication and SignalingCell SignalingCellsChemoattractantsChemotactic CytokinesChemotactic FactorsChemotaxinsChorioamnionitisCommunicationComplexDataExposure toFamilyFetal MembranesFetusGCP1GestationGrantHomolog of Drosophila TOLLHomologous Chemotactic CytokinesHumanHypoxanthine DehydrogenaseHypoxanthine OxidaseHypoxanthine-Xanthine OxidaseIL-8IL8IL8 geneImmuneImmunesIn VitroInfectionInfection of amniotic cavityInfection of amniotic sac and membranesInflammasomeInflammationInflammatoryInflammatory ResponseIntercrinesIntracellular Communication and SignalingInvestigatorsK60LipopolysaccharidesMarrow NeutrophilMaternal-Fetal ExchangeMediatingMediatorMiceMice MammalsMicroRNAsModelingModern ManMuramyl DipeptideMureinMurineMusNIAIDNational Institute of Allergy and Infectious DiseaseNatureNeutrophil ActivationNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteOutcomePathologicPathologyPattern recognition receptorPeptidoglycanPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPregnancyPregnancy ComplicationsPremature BirthPrematurely deliveringPreterm BirthProcessProductionPurine-Xanthine OxidaseReceptor ProteinRegulationResearchResearch PersonnelResearchersRiskRisk FactorsRoleSCYB8SIS cytokinesSigapurolSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSourceTIL4TLR proteinTLR2TLR2 geneTLR2 receptorTLR4TLR4 geneTLR7TLR7 geneTLR8TLR8 geneTSG-1TestingTissue membraneToll HomologueToll-Like Receptor 2Toll-Like Receptor 7Toll-Like Receptor 8Toll-Like Receptor Family GeneToll-like receptorsToll/Interleukin 1 Receptor-Like 4Toll/Interleukin 1 Receptor-Like 4 GeneToll/Interleukin 1 Receptor-Like Protein 4Transplacental ExposureTrioxopurineUric AcidWomanXanthine Oxidaseb-ENAPbacteria infectionbacterial diseasebiological signal transductionchemoattractant cytokinechemokinecomplement chemotactic factorcomplications during pregnancycytokineexosomeextracellularfetus membranein vitro testingin vivoinflammatory environmentinflammatory milieuinhibitorinjury to tissueintra-amniotic infectionintraamniotic infectionmaternal-fetal interfacemiRNAmouse modelmurine modelneutrophilnovelpregnancy-related complicationsprematurepremature childbirthpremature deliveryprematuritypreterm deliveryreceptorresponsesensorsocial roletherapeutic targettissue injurytoll-like receptor 4xanthine oxidase inhibitor
Description preview
Summary/Abstract
Chorioamnionitis - inflammation of the fetal membranes (FM) - is characterized by neutrophil infiltration and is
a major risk factor for preterm birth. Even in the absence of prematurity, chorioamnionitis can be detrimental to
the fetus. Despite a strong association between bacterial infection, chorioamnionitis, and preterm birth,…
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