grant
Mechanisms of Telomere-Mediated Lung Disease
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 10 Jul 2018Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AddressAffectAgeAgingAlveoli progenitorAlveoli stem cellApoptosisApoptosis PathwayBiologyBleoBleomycinCell AgingCell BodyCell SenescenceCellsCellular AgingCellular SenescenceChromosomesChronicClinicalCommunitiesDNA DamageDNA InjuryDNA SequenceDNA mutationDataDefectDevelopmentDiseaseDisorderDysfunctionElderlyEnvironmental ExposureEpithelial CellsEpitheliumFailureFibroblastsFibrosing AlveolitisFibrosisFunctional disorderGene variantGenesGenetic ChangeGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic defectGenetic mutationGenetic propensityHistologicHistologicallyHumanImageIn VitroIndividualInflammationInflammatoryInherited PredispositionInherited SusceptibilityInjuryInterstitial Lung DiseasesLateralLengthLinkLungLung Alveolar EpitheliaLung CapacityLung DiseasesLung Respiratory SystemLung Tissue FibrosisMapsMeasuresMediatingMethodologyMiceMice MammalsModelingModern ManMolecularMurineMusMutationOnset of illnessOrganOrganoidsOther GeneticsPathogenesisPathogenicityPathologicPatientsPeripheralPersonsPhysiologyPhysiopathologyPredispositionProcessProgenitor CellsProgrammed Cell DeathProteinsPulmonary DiseasesPulmonary DisorderPulmonary FibrosisRegenerative capacityReplicative SenescenceReportingResearch ResourcesResourcesRisk FactorsRoleSomatic MutationSpatial DistributionStem Cell likeSusceptibilityTechniquesTelomeraseTelomere MaintenanceTelomere Maintenance GeneTelomere ShorteningTestingVariantVariationWorkadvanced ageaged miceaged mouseagesallelic variantalveolar epitheliumalveolar progenitoralveolar stem celldevelopmentaldiffuse interstitial pulmonary fibrosisdisease of the lungdisease onsetdisorder of the lungdisorder onsetelderly miceepithelial repairfibrosis in the lunggenetic etiologygenetic mechanism of diseasegenetic variantgenetic vulnerabilitygenetically predisposedgenome mutationgenomic variantgeriatricidiopathic pulmonary fibrosisimage-based methodimagingimaging methodimaging modalityimprovedinjuriesinjury responseinterstitiallife spanlifespanlung disorderlung fibrosislung repairlung tissue repairmolecular phenotypenew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachold micepathophysiologypreventpreventingprogenitor capacityprogenitor cell functionprogenitor cell likeprogenitor functionprogenitor-likeproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialpulmonarypulmonary repairregeneration abilityregeneration capacityrepairrepairedreplicative agingresponseresponse to injurysenescencesenescentsenior citizensocial rolesomatic variantstemstem and progenitor cell functionstem and progenitor functionstem cell characteristicsstem cell functionstem cellsstem-likestemnesssurfactant deficiencytelomeretelomere attritiontool
Description preview
Abstract
Telomere dysfunction has emerged as a primary contributor to diseases within the human lung. Over the past
five years, our group has shown that telomere dysfunction limits the proliferative capacity of lung epithelial cells
and renders the lung susceptible to injury. In addition, we have found that the senescent lung epithelium secrets
a…
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