grant
Mechanisms of Post-transcriptional Gene Regulation by RNA Binding Proteins
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Apr 2020Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025ALS pathologyAlternate SplicingAlternative RNA SplicingAlternative SplicingAntigenic DeterminantsAwardBindingBinding DeterminantsC-terminalCancersCell CompartmentationCell CompartmentationsChromatinComplexCryo-electron MicroscopyCryoelectron MicroscopyDevelopmentDiseaseDisorderElectron CryomicroscopyEpitopesFamilyFunctional RNAFundingG15Gene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenesIntervening SequencesIntronsLUCA15MALAT1MALAT1 geneMalignant NeoplasmsMalignant TumorMediatingMessenger RNAMethodsMolecular InteractionNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronsNon-Polyadenylated RNANoncoding RNANontranslated RNANuclearPTB ProteinPTB Splicing FactorPeptidesPolypyrimidine Tract-Binding ProteinPost-Transcriptional ControlPost-Transcriptional RegulationPre-mRNAProcessProductivityProteinsPublicationsRBM5RBM5 geneRNARNA Gene ProductsRNA HelicaseRNA SplicingRNA metabolismRNA, Messenger, PrecursorsRNA-Binding Motif Protein 5RNA-Binding ProteinsReactionRegulationRibonucleic AcidRibonucleoproteins, Small, U1Ribonucleoproteins, Small, U2RoleScientific PublicationSmall Nuclear RNPSmall Nuclear Ribonucleoprotein ParticleSmall Nuclear RibonucleoproteinsSpliceosome AssemblySpliceosome Assembly PathwaySplicingStructureSynapsesSynapticTestingTranslationsU1 Small Nuclear RibonucleoproteinU1 snRNPU2 Small Nuclear RibonucleoproteinU2 snRNPUntranslated RNAamyotrophic lateral sclerosis pathologycryo-EMcryoEMcryogenic electron microscopydevelopmentalhuman diseasein vivoinsightmRNAmRNA Precursormalignancymetastasis-associated lung adenocarcinoma transcript 1neoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronalneuronal degenerationnoncodingp57 Cytoplasmic RNA-Binding ProteinpPTBparticlepathology in ALSpost-transcriptional gene regulationposttranscriptionalself assemblysnRNPsocial rolesynapsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranslation
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PROJECT SUMMARY/ABSTRACT
This MIRA award supports our studies of how RNA binding proteins regulate alternative splicing and other
posttranscriptional steps in mammalian gene expression. The previous funding period was very productive with
multiple publications. We developed new methods and we discovered new interactions and new functions for…
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