grant
Mechanisms of photoreceptor outer segment assembly
Organization UPSTATE MEDICAL UNIVERSITYLocation SYRACUSE, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAffinityApicalBackBindingBlindnessCarrier ProteinsCell BodyCellsCiliaComplementComplement ProteinsCone PhotoreceptorsDNA mutationDiffusionDimerizationDorsumEventEyeEyeballFluorescence Light MicroscopyFluorescence MicroscopyFrequenciesG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGenetic ChangeGenetic defectGenetic mutationGoalsGolgiGolgi ApparatusGolgi ComplexIndividualKnock-outKnockoutKnowledgeLightLocationMaintenanceMammaliaMammalsMath ModelsMembraneMiceMice MammalsMicroscopyModelingMolecularMolecular InteractionMotorMovementMurineMusMutationNatureOpsinPatientsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellProcessProtein DimerizationProteinsResolutionRetinal ConeRetinal DegenerationRhodopsinRodRod-OpsinRods and ConesRoleSightSiteStructureTimeTitrationsTransport Protein GeneTransport ProteinsTransporter ProteinVertebrate PhotoreceptorsVisionVisual PurpleVisual ReceptorWorkapical membranebasebasesbody movementcomplementationcone celldegenerative retina diseasesdiffuseddiffusesdiffusingdiffusionsdimergenome mutationmathematic modelmathematical modelmathematical modelingmembrane structuremouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyparticleperipherinphotoreceptor discresolutionsrestore sightrestore visionretina degenerationretinal degenerativeretinal degenerative diseasessight restorationsocial rolesuper high resolutionsuperresolutionthree dimensionaltissue fixingultra high resolutionvesicle transportvesicular transportvision lossvision restorationvisual functionvisual loss
Description preview
Project Summary/Abstract:
In this proposal we will address one of the major unanswered questions in vision: the mechanism
of rhodopsin delivery and loading into new photoreceptor discs. This perpetual process is
particularly robust in rods where, for mammals, the daily delivery of 30 million rhodopsins supports
the formation of 80 new discs in…
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