grant
Mechanisms of Muscle Adaptations in Aging and Exercise
Organization OHIO UNIVERSITY ATHENSLocation ATHENS, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY202621+ years oldActin-Activated ATPaseAcuteAddressAdmissionAdmission activityAdultAdult HumanAffectAgeAgingAmericanAntigensAttenuatedBinding ProteinsBiologyC57BL/6 MouseCessation of lifeChronicComplementComplement ProteinsDataDeathDecline in mobilityDecrease in mobilityDecreased mobilityDiminished mobilityEconomicsEffectivenessExerciseExhibitsExposure toFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsGene ExpressionGenesGeneticGoalsHealthHealth CareHistologicHistologicallyHospital AdmissionHospitalizationHumanIn VitroIndividualInjuryIsometric ExerciseIsometricsLigand Binding ProteinLigand Binding Protein GeneLinkMeasuresMediatingMediatorMetabolicMethodologyMiceMice MammalsMobility declineMobility impairmentModelingModern ManMolecularMurineMusMuscleMuscle TissueMuscle-Setting ExerciseMyosin ATPaseMyosin Adenosine TriphosphataseMyosin AdenosinetriphosphataseMyosinsNursing HomesPhysiologicPhysiologicalProtein BindingProteinsProteomicsPublic HealthPublishingQOLQuality of lifeRNA BindingRNA StabilityRNA boundRNA-Binding ProteinsReduced mobilityReduction in mobilityRegulationResearchRibonucleosidesRiskSkeletal MuscleSkeletal muscle injurySocietiesStatic ExerciseStimulusSystemTechniquesTestingTherapeuticTrainingTransgenic MiceUnited StatesVoluntary MuscleWorkadulthoodage associatedage correlatedage dependentage linkedage relatedage specificaged muscleagesaging of muscleattenuateattenuatesbound proteinbuild resiliencebuild resiliencycomplementationdevelop resiliencedevelop resiliencydisabilitydisability riskeconomicenhance healthspanenhance resilienceenhance resiliencyexercise trainingexperienceexperimentexperimental researchexperimental studyexperimentsextend healthspanextending healthy lifespanfacilitate resiliencefall riskfallsgain of functionhealthspanhealthspan extensionhealthy life spanimmunogenimprove healthspanimprove resilienceimprove resiliencyimprovedin vivo Modelincrease healthspanincrease resilienceincrease resiliencyindexinginhibitorinjuriesinjury recoveryinnovateinnovationinnovativeloss of functionmortalitymouse modelmurine modelmuscle agingmuscle strengthmuscularnovelnursing homeolder adultolder adulthoodoverexpressoverexpressionpharmacologicpreventpreventingprolong healthspanpromote healthspanpromote resiliencepromote resiliencyprotective effectprotein expressionrecovery after injuryrecovery following injuryrecovery post injuryresilienceresilience developmentresilientresponsesarcopeniasarcopenicsmall molecular inhibitorsmall moleculesmall molecule inhibitorsocialtranscriptomics
Description preview
PROJECT SUMMARY/ABSTRACT
The United States is experiencing a significant demographic shift, with the number of older adults projected to
increase by 18 million in the next decade, reaching 90 million by 2050. This surge will transform healthcare needs
and place considerable strain on social and economic systems, particularly due to age-related…
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