grant
Mechanisms of migraine chronification and reversal
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025Afferent NeuronsAldesleukin GeneAutoimmune DiseasesBehavioralBody TissuesBone-Derived Transforming Growth FactorCD3CD3 AntigensCD3 ComplexCD3 moleculeCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCSIFCSIF-10Calcitonin Gene-Related PeptideCell BodyCell Communication and SignalingCell SignalingCellsCephalalgiaCephalgiaCephalodyniaCervicalChronicChronic HeadachesCo-StimulatorCostimulatorCranial PainCytokine Synthesis Inhibitory FactorDefectDevelopmentDiseaseDisorderDoseDuraDura MaterDysfunctionEpidermal Thymocyte Activating FactorEquilibriumExhibitsFBJ Murine Osteosarcoma Viral Oncogene HomologFOS Family ProteinFOS ProteinFaceFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoundationsFunctional disorderFunctional impairmentFutureGasser's GanglionGasserian GanglionGlyceryl TrinitrateHead PainHeadacheHortega cellHypersensitivityIL-10IL-2IL-2 GeneIL10IL10AIL2IL2 ProteinIL2 geneImageImmuneImmune Cell ActivationImmunesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInflammatoryInterleukin 10 PrecursorInterleukin 2Interleukin 2 PrecursorInterleukin 2 Precursor GeneInterleukin IIInterleukin-10Interleukin-2Interleukin-2 GeneInterleukine 2Interleukine 2 PrecursorInterleukine IIIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLymphocyte Mitogenic FactorMaintenanceMeasuresMediatingMeningealMiceMice MammalsMicrogliaMigraineMigraine HeadacheMilk Growth FactorMitogenic FactorModelingMolecular TargetMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuroimmuneNeuronsNeuropeptidesNitroglycerinNull MouseOKT3 antigenPACAPPathogenesisPathway interactionsPatientsPeptidesPeripheralPhysiopathologyPlatelet Transforming Growth FactorR peptideRecurrenceRecurrentRegulatory T-LymphocyteResolutionSemilunar GanglionSensory NeuronsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSourceStaining methodStainsStimulusStructure of trigeminal ganglionSubgroupT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell growth factorT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Growth FactorT-Cell Growth Factor GeneT-Cell Stimulating FactorT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT-cell therapeuticsT-cell transfer therapyT3 AntigensT3 ComplexT3 moleculeT8 CellsT8 LymphocytesTCGF GeneTGF BTGF-Beta 1TGF-Beta1TGF-betaTGF-βTGFBTGFB1TGFB1 geneTGFbetaTGFβTestingThymocyte Stimulating FactorTissuesTransforming Growth Factor Beta 1Transforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTranslational ResearchTranslational ScienceTregTrigeminal GangliasTrigeminal GanglionWorkadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyautoimmune conditionautoimmune disorderautoimmunity diseasebalancebalance functionbehavioral sensitizationbiological signal transductionc-fos Proteincellular sensitizationcellular targetingconditional knock-outconditional knockoutdevelopmentaldorsal horndrug discoveryexperimentexperimental researchexperimental studyexperimentsface skinfacesfacialfacial skinflow cytophotometrygitter cellhead acheimagingimmune activationimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinsightknockout genemesogliamicroglial cellmicrogliocytemigraine therapymigraine treatmentmouse modelmurine modelneuronalnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynociceptive responsenovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypathwayperipheral bloodperivascular glial cellpituitary adenylate cyclase activating peptidepituitary adenylate cyclase activating polypeptidepolypeptideregulatory T-cellsresolutionsresponsetherapeutic T-cell platformthymus derived lymphocytetransforming growth factor beta1translation researchtranslational investigationtrinitrate 1,2,3-Propanetriol
Description preview
PROJECT SUMMARY/ABSTRACT
Chronic migraine is highly debilitating, poorly understood, and with limited treatment options. Although the
activation of many pro-inflammatory immune cells has been shown to contribute to migraine pathophysiology,
the involvement of CD3+ T lymphocytes, especially the immunosuppressive regulatory T (Treg) cells, in…
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