grant
Mechanisms of Ischemic Kidney Injury and Repair
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Sept 1984Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2025ARP1 proteinATR geneATR proteinATR protein kinaseATR serine/threonine kinaseAbscissionAccelerationAcuteAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAdventitial CellAdverse effectsAgingAnimalsAtaxia Telangiectasia and Rad3 Related ProteinAtaxia Telangiectasia and Rad3-RelatedAtaxia-Telangiectasia and Rad3-Related GeneAutophagocytosisBody TissuesBreast CancerBreast Cancer CellBromodomainCOUP transcription factor IICOUP-TF IICOUP-TFIICell AgingCell BodyCell CycleCell Cycle ArrestCell DeathCell Death InhibitionCell Division CycleCell SenescenceCellsCellular AgingCellular SenescenceCellular injuryCessation of lifeChemosensitizationChemosensitization/PotentiationChemotactic CytokinesChronicChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalComplementComplement InactivatorsComplement InhibitorsComplement ProteinsCoupledDNA DamageDNA Damage RepairDNA InjuryDNA RepairDeathDown-RegulationDysfunctionEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsErinaceidaeExcisionExtirpationFRAP-Related Protein-1FRP1FamilyFemaleFibroblastsFibrosisFunctional disorderGenerationsGeneticGlycolysisGoalsGrantGrowth AgentsGrowth FactorGrowth SubstancesHedgehogsHomologous Chemotactic CytokinesHumanImpairmentInflammatoryInjuryInjury to KidneyIntercrinesIntermediary MetabolismIschemiaKO miceKidneyKidney Urinary SystemKnock-out MiceKnockout MiceLamin ALamin Type AMEC1Malignant Breast NeoplasmMediatorMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManModificationMorbidityMorbidity - disease rateMurineMusMyofibroblastNR2F2NephrologyNuclearNuclear LaminNull MouseOperative ProceduresOperative Surgical ProceduresOrganoidsPathway interactionsPatientsPericapillary CellPericytesPerivascular CellPersonsPhenotypePhysiopathologyPotentiationPredispositionPreventative strategyPrevention strategyPreventive strategyProcessProductionProteinsProteins Growth FactorsProximal Kidney TubulesPublicationsRad3 Related ProteinRapamuneRapamycinRemovalRenal CellReplicative SenescenceRodentRodentiaRodents MammalsRoleRouget CellsSCKLSCKL1SIS cytokinesScientific PublicationSirolimusSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSusceptibilitySystemTherapeuticTissuesTransgenic MiceTransgenic OrganismsUnscheduled DNA SynthesisUrologyWild Type MouseWorkaccelerated agingaccelerated biological ageaccelerated biological agingacute kidney injuryage accelerationagedapoAI regulatory protein-1apolipoprotein AI regulatory protein 1ataxia telangiectasia and Rad3 relatedautophagybreast tumor cellcell damagecell injurycellular damagechemoattractant cytokinechemokinechicken ovalbumin upstream promoter-transcription factor IIchronic kidney diseasecomplementationdamage to cellsdevelop therapyeffective therapyeffective treatmentepigeneticallyepigenomefatty acid oxidationhuman derived pluripotent stem cellhuman pluripotent stem cellin vivoindexingineffective therapiesineffective treatmentinjuriesinjury and repairinjury responseinjury to cellsinterstitialintervention developmentischemia injuryischemic injurykidney cellkidney epithelial cellkidney injurykidney ischemiakidney repairknock-downknock-out animalknockdownknockout animallamin A precursormalemalignant breast tumormembermortalitymouse modelmurine modelnecrocytosisnovelnuclear receptor subfamily 2, group F, member 2pathophysiologypathwayprelamin Aprogenitor cell poolprogenitor cell populationprogenitor poolprogenitor populationprotein activationrenalrenal injuryrenal ischemiarenal proximal tubulerepairrepairedreplication stressreplicative agingresectionresponseresponse to injurysenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescentsenescent associated secretomesenescent associated secretory phenotypesocial rolespheroidsstem and progenitor cell populationstem cell poolstem cell populationsurgerytherapy developmenttransgenictreatment developmentwildtype mouse♀♂
Description preview
Acute kidney injury (AKI) remains a very important and growing unmet therapeutic need. The
overall goal of the studies proposed in this competitive renewal application for a grant which is
now in its 37th year of support remains to understand the mechanisms involved in kidney cell
injury and repair in order to develop therapeutic strategies for…
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