grant
Mechanisms of Impaired Inflammation Resolution in Cystic Fibrosis Lung Disease
Organization DARTMOUTH-HITCHCOCK CLINICLocation LEBANON, UNITED STATESPosted 1 Aug 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025Airway failureBasal Transcription FactorBasal transcription factor genesBindingBlood NeutrophilBlood Polymorphonuclear NeutrophilBronchiectasisBronchoscopyCD14CD14 geneCF lung diseaseCF patientsCFTRCFTR ProteinCell BodyCellsChronicClinical Medical SciencesClinical MedicineCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDNA mutationDataFailureGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ChangeGenetic defectGenetic mutationGlycolysisGoalsImmuneImmunesImpairmentInflammationInflammatoryInflammatory ResponseIntermediary MetabolismInvestigationKnowledgeLength of LifeLipidsLong-term infectionLongevityLungLung InflammationLung Respiratory SystemLung infectionsMacrophageMarrow NeutrophilMediatingMetabolic PathwayMetabolic ProcessesMetabolismMicroRNAsMissionMolecular InteractionMorbidityMorbidity - disease rateMucoviscidosisMutationMφNational Institutes of HealthNeutrophilic GranulocyteNeutrophilic LeukocyteOxidative StressPathogenesisPersonsPhenotypePneumonitisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPublic HealthPulmonary Cystic FibrosisPulmonary InflammationQOLQuality of lifeRegulator GenesResearchResolutionRespiratory FailureSamplingSortingSurfaceTestingTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional Regulatory ElementsUnited States National Institutes of Healthchronic infectioncohortcystic fibrosis lungcystic fibrosis lung diseasecystic fibrosis patientscystic fibrosis transmembrane regulatordifferential expressiondifferentially expressedextracellular vesiclesgenetic trans acting elementgenome mutationhuman diseasehuman subjectimprovedindividuals with CFindividuals with cystic fibrosisinnovateinnovationinnovativemiRNAneutrophilnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetpatients with CFpatients with cystic fibrosispersistent infectionpreventpreventingpulmonary infectionsregulatory generesolutionstrans acting elementtranscription factortranscriptional differencestranslational studyvesicle releasevesicular release
Description preview
Patients with cystic fibrosis (CF) suffer from chronic infections and lung inflammation leading to bronchiectasis
and, ultimately, respiratory failure. Although recent advances, including the approval of highly effective CFTR
modulator therapy (HEMT), have improved the overall quality of life of people with CF (PwCF), chronic
infection and…
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