grant
Mechanisms of immunological memory-mediated pathogenesis in chronic autoimmune uveitis
Organization SCHEPENS EYE RESEARCH INSTITUTELocation BOSTON, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202521+ years oldAcuteAcute DiseaseAddressAdrenal Cortex HormonesAdultAdult HumanAgeAnimalsAntigensApoptosisApoptosis PathwayAssayAutoimmune DiseasesBeta Cadherin-Associated ProteinBeta-1 CateninBioassayBiological AssayBiologyBlindnessBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8BCD8B1CD8B1 geneCUL-2Cell BodyCell FunctionCell PhysiologyCell ProcessCell SurvivalCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessChronicChronic DiseaseChronic IllnessClinicalClinical ManagementCorticoidsCorticosteroidsDataDependenceDevelopmentDiminished VisionDiseaseDisease ResistanceDisorderEconomic BurdenElectroretinographyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFutureGene TranscriptionGenetic TranscriptionGlycolysisHIF 1HIF-1 proteinHIF1HIF1 proteinHealth Care CostsHealth CostsHistopathologyHumanHypoxiaHypoxia Inducible FactorHypoxicImmune memoryImmune responseImmunoblottingImmunologic MemoryImmunological MemoryImmunotherapeutic agentIn VitroIncidenceIncrease lifespanIndividualInfiltrationInflammationInflammatoryIntermediary MetabolismKnowledgeLYT3LaboratoriesLength of LifeLongevityLow VisionMediatingMediatorMedicalMetabolicMetabolic PathwayMetabolic ProcessesMetabolismModelingModern ManMolecularO elementO2 elementOxygenOxygen DeficiencyPRO2286Partial SightPathogenesisPathogenicityPathway interactionsPatientsPlayPopulationProgrammed Cell DeathProliferatingProteinsPublic HealthRNA ExpressionReduced VisionResistanceRetinaRoleSeverity of illnessSightSubcellular ProcessSubnormal VisionT memory cellT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTherapeuticTissuesTranscriptionTransgenic MiceTransgenic ModelUpregulationUveitisViral CancerViral DiseasesVirus DiseasesVisionVisual impairmentWestern BlottingWestern ImmunoblottingWorkacute disease/disorderacute disorderadult youthadulthoodagesanamnestic reactionantigen-specific T cellsautoimmune conditionautoimmune disorderautoimmune reactivityautoimmune uveitisautoimmunity diseaseautoreactivitybeta catbeta cateninboost longevitychronic disorderdevelopmentaldisease severityeconomic impactefficacious therapyefficacious treatmentelectroretinogramelongating the lifespanenhance longevityexperimentexperimental researchexperimental studyexperimentsextend life spanextend lifespanextend longevityflow cytophotometryfoster longevityglucose uptakehost responsehypoxia inducible factor 1immune drugsimmune system responseimmune-based therapeuticsimmunogenimmunologic therapeuticsimmunoresponseimmunotherapeuticsimmunotherapy agentimprove lifespanimprove longevityimprovedin vivolifespan extensionmemory CD4 T cellmemory CD4 T lymphocytememory T lymphocytememory recallmouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoverexpressoverexpressionpathwayproductivity lossprolong lifespanprolong longevitypromote lifespanpromote longevityprotein blottingresistance to diseaseresistantresistant diseaseresistant to diseaseresponsesecondary immune responsesensorside effectsocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicssupport longevitytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetranscriptional reprogrammingtransgenic traittranslational studyviral infectionvirus infectionvirus-induced diseasevision impairmentvision lossvisual functionvisual lossvisually impairedyoung adultyoung adult ageyoung adulthoodβ-catenin
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PROJECT SUMMARY / ABSTRACT
Chronic autoimmune uveitis is often a treatment-resistant disease, leading to irreversible vision loss in a
significant number of patients, particularly in the working-age population, and thus adds a substantial socio-
economic burden due to consequent healthcare costs and productivity loss. The preponderance of previous…
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