grant
Mechanisms of Immune Dysfunction after Trauma and Surgical Sepsis
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Jun 2018Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AcuteAgeAtlasesBloodBlood Reticuloendothelial SystemBlood SampleBlood specimenCell BodyCellsCessation of lifeChromatinCirculationComparative StudyCritical IllnessCritically IllDataData SetDeathDevelopmentDysfunctionEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFunctional disorderFundingGene ExpressionHemorrhagic ShockHumanImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunosuppressionImmunosuppression EffectImmunosuppressive EffectLeadLipidsMeasuresModern ManMorbidityMorbidity - disease rateMultiomic DataOperative ProceduresOperative Surgical ProceduresOrganOutcomePBMCPatientsPatternPb elementPeripheral Blood Mononuclear CellPhysiopathologyPolycombPredispositionProteinsPublishingResearchResearch ResourcesResourcesSecondary toSepsisSurgicalSurgical InterventionsSurgical ProcedureSusceptibilityTechnologyTimeTranslatingTraumaTrauma patientWorkagesbiomarker identificationcell typecritical injuryderepressiondevastating injurydevelopmentalepigeneticallyheavy metal Pbheavy metal leadhigh dimensional dataidentification of biomarkersidentification of new biomarkersimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimproved outcomeinsightinternet resourcemarker identificationmouse modelmultidimensional datamultidimensional datasetsmultiomicsmultiple omic datamultiple omicsmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targeton-line compendiumon-line resourceonline compendiumonline resourcepanomicspathophysiologypatient stratificationpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprotein expressionresponsesecondary infectionsevere injurysexsingle cell genomicsstratified patientsurgerysystemic inflammationsystemic inflammatory responsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targetweb resourceweb-based resource
Description preview
Project Summary/Abstract
Trauma and Surgical Sepsis are among the leading causes of morbidity and death worldwide. Both of these acute
insults can lead to immune dysfunction that then contributes to a state of persistent critical illness. This immune
dysfunction is manifested by an excessive systemic inflammatory response that can lead to organ…
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