grant
Mechanisms of hypoxia-mediated memory impairment in an animal model of acute respiratory failure in preterm survivors
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 15 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20250-4 weeks old21+ years oldAMPA ReceptorsAbbreviationsAcquired brain injuryAction PotentialsAcuteAcute respiratory failureAdolescentAdolescent YouthAdultAdult HumanAgonistAmmon HornAnimal ModelAnimal Models and Related StudiesBehavioralBrainBrain Hypoxia-IschemiaBrain InjuriesBrain Nervous SystemCa2+-Activated K+ ChannelsCalcium-Activated K+ ChannelsCalcium-Activated Potassium ChannelCell DeathCell NucleusCerebral PalsyCerebrumChild Development DisordersChronicClinical ManagementComplicationCornu AmmonisCritical IllnessCritically IllDataDevelopmentDevelopmental DisabilitiesEPSPElementsEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventExcitatory Postsynaptic PotentialsExposure toFeedbackGene ExpressionGene TranscriptionGeneralized GrowthGenetic TranscriptionGliaGlial CellsGlutamate ReceptorGlutamatesGrowthHippocampusHypoxiaHypoxicImmediate MemoryImpairmentIn VitroInflammationIschemiaK channelKolliker's reticulumL-GlutamateLearningLearning DisabilitiesLearning disabilityLifeLinkLong-Term PotentiationLungLung Respiratory SystemMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMemory DeficitMemory impairmentMiceMice MammalsMolecularMurineMusN-Methyl-D-Aspartate ReceptorsN-Methylaspartate ReceptorsNMDA Receptor-Ionophore ComplexNMDA ReceptorsNMR ImagingNMR TomographyNeonatalNerve CellsNerve DegenerationNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeural TransmissionNeurocyteNeurogliaNeuroglial CellsNeurological disabilityNeuron DegenerationNeuronal TransmissionNeuronsNewborn InfantNewborn resuscitationNewbornsNon-neuronal cellNonneuronal cellNuclearNuclear Magnetic Resonance ImagingNucleusO elementO2 elementOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOutcomeOxygenOxygen DeficiencyPathway interactionsPotassium ChannelPotassium Ion ChannelsPredispositionPremature BirthPremature InfantPrematurely deliveringPreterm BirthPropertyProtein-Serine KinaseProtein-Serine-Threonine KinasesProtein-Threonine KinaseRNA ExpressionRNA SeqRNA sequencingRNAseqRiskRoleSchool-Age PopulationSerine KinaseSerine-Threonine KinasesSerine/Threonine Protein Kinase GeneSeveritiesShort-Term MemorySingle-Nucleus SequencingSpinal ColumnSpineSurvivorsSusceptibilitySynapsesSynapticSynaptic TransmissionSynaptic plasticityTestingThreonine KinaseTissue GrowthTranscriptionUterusVertebral columnZeugmatographyacute hypoxemic respiratory failureacute hypoxic respiratory failureacute onset hypoxemic respiratory failureadult animaladult youthadulthoodaxon signalingaxon-glial signalingaxonal signalingbackbonebrain damagebrain-injuredcell typecerebralclinical relevanceclinically relevantcognitive disabilitycognitively disabledconditioned feardensitydevelop therapydevelopmentaldiagnostic approachdiagnostic strategyepigeneticallyfear conditioningfetalfetal hypoxiafetus hypoxiaglia signalingglial signalingglutamatergicgray matterhippocampalhypoxia neonatorumhypoxia/ischemiaimprovedin vivoinfants born prematureinfants born prematurelyinnovateinnovationinnovativeintervention developmentjuvenilejuvenile humanlight microscopymature animalmemory dysfunctionmodel of animalmouse modelmurine modelnecrocytosisneonatal careneonatal hypoxianeonatal resuscitationneonatenerve cell deathnerve cell lossnerve cementnerve signalingneural degenerationneural signalingneurobehavioral testneurodegenerationneurodegenerativeneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuronal signalingneurotransmissionnew approachesnew diagnosticsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynewborn childnewborn childrennext generation diagnosticsnext generation therapeuticsnovelnovel approachesnovel diagnosticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyontogenypathwaypostnatalprematurepremature babypremature childbirthpremature deliverypremature infant humanpremature neonatespremature newbornprematuritypreterm babypreterm deliverypreterm infantpreterm infant humanpreterm neonatepreterm newbornpreventpreventingresponsesNuc-Seqschool agesingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolesubstantia griseasuper high resolutionsuperresolutionsynapsetherapy developmenttranscriptome sequencingtranscriptomic sequencingtranscriptomicstreatment developmentultra high resolutionverbalwhite matter injurywombworking memoryyoung adultyoung adult ageyoung adulthood
Description preview
Summary
Due to advances in neonatal care, most preterm infants no longer develop cerebral palsy from hypoxic-ischemic
white matter injury (WMI). However, up to 50% develop gray matter associated cognitive and learning
disabilities by school age that persist throughout life. These developmental disabilities are commonly associated
with a systemic…
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