grant
Mechanisms of HIV-associated Hypertension
Organization AUGUSTA UNIVERSITYLocation AUGUSTA, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS preventionAIDS-Related DisorderAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdoptive TransferAffectAgingAnimal ModelAnimal Models and Related StudiesAntibodiesAortaBP controlBP managementBlast TransformationBlastogenesisBlood PressureBone Marrow GraftingBone Marrow TransplantBone Marrow TransplantationCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCause of DeathCessation of lifeChronicCirculationClinicClinical TrialsCo-cultureCocultivationCocultureCoculture TechniquesDataDeathDevelopmentDiseaseDisease Associated with AIDSDisorderEndothelial CellsEndotheliumExhibitsExposure toFemaleGene TranscriptionGeneHomologGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic TranscriptionHIVHIV PreventionHIV tat ProteinHIV/AIDS preventionHeart VascularHomologHomologous GeneHomologueHortega cellHumanHuman Immunodeficiency VirusesHypertensionImpairmentIncubatedIndividualInflammationInfusionInfusion proceduresInterleukinsKnowledgeLAV-HTLV-IIILife ExpectancyLymphadenopathy-Associated VirusLymphoblast TransformationLymphocyte ActivationLymphocyte StimulationLymphocyte TransformationMarrow TransplantationMediatingMiceMice MammalsMicrogliaModern ManMolecularMurineMusNADPH OxidaseOutcomePersonsPhenotypePremature AgingPremature aging syndromeProductionProteinsRNA ExpressionRecombinant DNA TechnologyRelaxationReportingResearch SpecimenRoleSpecimenSympathetic Nervous SystemSystemT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTherapeuticTrans-Activation of Transcription ProteinTrans-Activator of Transcription of HIVTransactivating Regulatory ProteinTranscriptionVascular DiseasesVascular DisorderVascular Endothelial CellVascular Hypertensive DiseaseVascular Hypertensive DisorderVascular agingViral Gene ProductsViral Gene ProteinsViral ProteinsViral reservoirViremiaVirus reservoirVirus-HIVWild Type MouseWomanaberrant agingabnormal agingaccelerated agingaccelerated biological ageaccelerated biological agingage accelerationantiretroviral therapyantiretroviral treatmentarterial stiffeningarterial stiffnessartery stiffeningartery stiffnessblood pressure controlblood pressure managementblood vessel disordercardiovascular disordercardiovascular riskcardiovascular risk factorcirculatory systemdevelopmentaldysfunctional age related changedysfunctional agingearly onsetendothelial dysfunctionexposed human populationgenetically engineeredgitter cellhigh blood pressurehuman exposurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimpaired agingimprovedin vivoinfusionsinhibitormaladaptive agingmalemenmesogliamicroglial cellmicrogliocytemodel of animalmouse modelmurine modelneural inflammationneuroinflammationneuroinflammatoryneutralizing antibodynew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathological age related changespathological agingperivascular glial cellpharmacologicprematureprematuritypreventpreventingsenescencesenescentsenolyticssocial roletat Proteinthymus derived lymphocytevascular dysfunctionvasculature agingvasculopathyviraemiaviral sepsisvirus proteinvirusemiawildtype mouse♀♂
Description preview
PROJECT SUMMARY
Over the last few decades, the advent of combination antiretroviral therapy has led to a profound suppression of
HIV replication and dramatically increased life expectancy in people with HIV (PWH). As a consequence, the
spectrum of diseases related to HIV has shifted from opportunistic AIDS-related disorders towards a premature…
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