grant
Mechanisms of Hepatocyte Polarization and Apical Tube Formation
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Jul 2021Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026Actin FilamentsActin-Activated ATPaseActinsAddressAdherens JunctionAdhering JunctionAdhesive JunctionAnchoring JunctionApicalArchitectureBileBile CanaliculiBile Duct ObstructionBile JuiceBile fluidBiliary StasisBindingBiogenesisBiologic ModelsBiologicalBiological ModelsCadherin-1CadherinsCancersCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationCholestasisCommon Rat StrainsCytokinesisCytoplasmic DivisionDataDefectDevelopmentDrug Metabolic DetoxicationDrug Metabolic DetoxificationE-CadherinEngineeringEngineering / ArchitectureEnigma HomologEpithelial Calcium-Dependent Adhesion ProteinEpithelial CellsEpithelial-CadherinEpitheliumExhibitsFetal LiverGenomicsGeometryHep G2HepG2HepG2 cell lineHepaticHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatocyteHepatomaHumanHuman EngineeringImpairmentIn VitroLIM Domain ProteinLIM Protein RILLinkLiverLiver CellsLiver Cells CarcinomaLiver RegenerationLiver diseasesMYH12MYO5MYO5AMYO5A geneMaintenanceMalignant NeoplasmsMalignant TumorMediatingMembraneMetabolic Drug DetoxicationsMetabolism of Toxic AgentsMiceMice MammalsMicrofilamentsModel SystemModelingModern ManMolecularMolecular InteractionMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMorphogenesisMotorMurineMusMyofilamentsMyosin ATPaseMyosin Adenosine TriphosphataseMyosin AdenosinetriphosphataseMyosin, Heavy Chain 12MyosinsN-CadherinOccluding JunctionsOrigin of LifePhysiologicPhysiologicalPrimary carcinoma of the liver cellsProcessProductionProliferatingProtein BiosynthesisProteinsProteomicsPublic HealthRatRats MammalsRattusReversion-Induced LIM ProteinRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSerum ProteinsSiteSmall G-ProteinsSmall GTPasesSourceTechnologyTestingTight JunctionsTimeTubeTubularTubular formationUvomorulinValidationWorkZonula Occludensapical membranebile canaliculus structurebile formationbile obstructionbile occlusionbiologiccholestatic diseasescholestatic disordercholestatic liver diseasecholestatic liver disordercholestatic syndromescomparativedaughter celldetoxificationdevelopmentalezrinfetalhepatic body systemhepatic diseasehepatic organ systemhepatopathyhuman modelin vivoinsightknock-downknockdownliver carcinomaliver developmentliver disorderliver functionmalignancymembrane structuremodel of humanmorphogenetic processmouse modelmurine modelmyosin Vamyoxinneoplasm/cancerneuralphosphoprotein p81physiologic modelprotein synthesisradixinradixin proteinrhorho GTPase-activating proteinrhoGAPsocial rolespatial and temporalspatial temporalspatiotemporaltraffickingvalidations
Description preview
Project Summary/Abstract:
The vital functions of the liver—detoxification, serum protein synthesis, and bile production—critically depend
on the establishment of a unique hepatic polarity and the formation of bile canaliculi (BC). Defects in these
processes contribute to serious liver diseases, including cholestasis and hepatocarcinoma. Using the…
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