grant
Mechanisms of HBx Recognition and Epigenetic Regulation of HBV cccDNA
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 30 Mar 2026Deadline 29 Mar 2029
NIHUS FederalResearch GrantFY202630 nm Chromatin Fiber30 nm FiberATACAffectAnimal ModelAnimal Models and Related StudiesAntigensAssayAttenuatedAuxinsBasal Transcription FactorBasal transcription factor genesBindingBioassayBiochemicalBiological AssayBiologyCell BodyCellsChIP assayChaperoneChromatinChromatin AssemblyChromatin FiberChromatin ModelingChronic Hepatitis BCircular DNACognitive DiscriminationCore ParticleDNA SequenceDepositDepositionDiscriminationDiseaseDisorderDrugsElementsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventFeedbackGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic TranscriptionGoalsHBVHBV X proteinHBV cureHBV functional cureHBV infectionHBxHBxAgHepatic CellsHepatic Parenchymal CellHepatitis B InfectionHepatitis B VirusHepatitis B Virus-XHepatitis B X-ProteinHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatocyteHepatomaHistonesHost FactorHost Factor ProteinIn VitroIndividualInfectionIntegration Host FactorsInterferometryLPTNLabelLengthLife CycleLife Cycle StagesLiver CellsLiver Cells CarcinomaMNase-seqMaintenanceMapsMeasuresMediatingMedicationMethodsMicrococcal nuclease digestion of chromatin followed by sequencingMicrococcal nuclease-sequencingMnase-SequencingModelingMolecularMolecular ChaperonesMolecular InteractionNucleosome CoreNucleosome Core ParticleNucleosomesOncogenicPeptidesPersonsPharmaceutical PreparationsPlayPositionPositioning AttributePrecipitationPrimary carcinoma of the liver cellsRNA ExpressionRecombinantsRegulationRegulatory ProteinRoleSCM-1SCM-1aSCM1SCYC1TechniquesTestingTherapeuticTranscriptionTranscription Factor Proto-OncogeneTranscription Initiation SiteTranscription Start SiteTranscription factor genesTranscriptional ControlTranscriptional RegulationTransfectionVariantVariationViralViral ActivityViral FunctionViral GenesViral PathogenesisViral PhysiologyVirus ReplicationVisualizationWorkXCL1XCL1 geneattenuateattenuatesbiophysical analysisbiophysical approachesbiophysical methodologybiophysical methodsbiophysical studiesbiophysical techniqueschromatin immunoprecipitationchronic HBV infectionchronic hepatitis B infectionchronic hepatitis B virus infectionchronic infections with hepatitis B viruschronically infected with HBVchronically infected with hepatitis Bdrug/agentepigenetic gene silencingepigenetic regulationepigenetic silencingepigeneticallygenetic regulatory proteinglobal healthhepatitis B curehepatitis B functional curehepatitis B viral infectionhepatitis B virus X antigenhepatitis B virus X proteinhepatitis B virus curehepatitis B virus functional curehepatitis B virus infectionimmunogenimprovedinfected with HBVinfected with hepatitis Binfected with hepatitis B virusinfection with HBVinfection with hepatitis B virusinhibitorinsightlife courseliver carcinomamodel of animalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpharmacologicprecipitationspreventpreventingreconstitutereconstitutionregulatory gene productshRNAshort hairpin RNAsmall hairpin RNAsocial roletherapeutic targettranscription factortranscriptional transactivator hbxviral multiplicationviral replicationvirus multiplicationvirus pathogenesis
Description preview
PROJECT SUMMARY/ABSTRACT
Chronic Hepatitis B Virus (HBV) infection affects nearly 300 million individuals and is a leading cause of
hepatocellular carcinoma worldwide. HBV persistence relies on the establishment of 1) the viral covalently closed
circular DNA (cccDNA) minichromosome which serves as that viral transcriptional template and 2) the…
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