grant
Mechanisms of gene regulation by long noncoding RNAs
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025Angelman SyndromeAutoimmune StatusAutoimmunityAutoregulationBiologyCancersCausalityCerebroatrophic HyperammonemiaDataDiseaseDisorderEtiologyFunctional RNAGene Action RegulationGene Down-RegulationGene ExpressionGene Expression RegulationGene InactivationGene RegulationGene Regulation ProcessGene SilencingGene TranscriptionGenesGenetic DiseasesGenetic TranscriptionGenomeHappy Puppet SyndromeHealthHomeostasisHumanIntervening SequencesIntronsLinkLyonizationMalignant NeoplasmsMalignant TumorMediatingModern ManNon-Polyadenylated RNANoncoding RNANontranslated RNAOrganismOutcomePhenotypePhysiological HomeostasisPlayProcessProteinsPuppet ChildrenRNARNA ExpressionRNA Gene ProductsRNA ProcessingRNA SequencesRNA SplicingRNA analysisRNA and protein interactionRNA-Binding ProteinsRNA-Protein InteractionRepressionResearchRett DisorderRett SyndromeRibonucleic AcidRoleSplicingStructureTherapeuticTimeTranscriptionTranscription RepressionTranscriptional ControlTranscriptional RegulationUntranslated RNAVariantVariationWorkX ChromosomeX InactivationX-Chromosome Inactivationbiological systemscausationcell typedisease causationepigenetic regulationgene repressiongenetic conditiongenetic disorderglobal gene expressionglobal transcription profileinsightliving systemmalignancymammalian genomeneoplasm/cancernoncodingprogramspuppetlike syndromesocial roletranscriptional silencingtranscriptome
Description preview
ABSTRACT
Only about 1% of the mammalian genome encodes for protein yet 80% is transcribed, suggesting that noncoding
RNA has many roles in gene regulation. Our research program aims to delineate those roles and the
mechanisms involved. Over the next five years, our focus will be the study of long noncoding RNAs (lncRNAs)
that function to repress…
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