grant
Mechanisms of folate action during nervous system development
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 15 May 2019Deadline 31 May 2030
NIHUS FederalResearch GrantFY20260-4 weeks oldAKTActive Follow-upAdherens JunctionAdhering JunctionAdhesive JunctionAffectAkt proteinAnchoring JunctionApicalAssayBAP32 proteinBioassayBiologic ModelsBiological AssayBiological ModelsBirth DefectsBody TissuesCD2-associated proteinCD2AP proteinCancersCell BodyCell Communication and SignalingCell SignalingCell membraneCellsChiro-InositolCo-ImmunoprecipitationsCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCytoplasmic MembraneDataDedicationsDefectDegenerative Neurologic DisordersDependenceDeveloping fetusDiagnosisEmbryoEmbryonicEndocytosisEnriched FoodEnvironmentFailureFamilyFetal DeathFetal DevelopmentFetusFolateFolic AcidFortified FoodFundingGestationGoalsHumanImageIncidenceInfantInositolIntermediary MetabolismIntracellular Communication and SignalingInvestigationKinasesLC/MSMalignant NeoplasmsMalignant TumorMechanicsMediatingMembraneMembrane PotentialsMesoinositolMetabolic ProcessesMetabolismModel SystemModern ManMolecularMolecular FingerprintingMolecular ProfilingNamesNeonatal MortalityNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural Tube ClosureNeural Tube DefectsNeural Tube Developmental DefectsNeural degenerative DisordersNeural tubeNeurodegenerative DiseasesNeurodegenerative DisordersNeurologicNeurologic Degenerative ConditionsNeurologicalNeuronal DifferentiationNewborn InfantNewbornsOrganoidsPhb1 proteinPhb2 proteinPhenotypePhosphotransferase GenePhosphotransferasesPlasma MembranePlatannaPregnancyPreventative strategyPrevention strategyPreventive strategyProtein Kinase BProteinsProto-Oncogene Proteins c-aktPteroylglutamic AcidRAC-PK proteinRNA SeqRNA sequencingRNAseqRegulationResearchResting PotentialsRiskRoleScaffolding ProteinSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeStructureSupplementationTestingTissuesTransmembrane PotentialsTransphosphorylasesTraumaVitamin MVitaminsXenopus laevisactive followupapical membranebiological signal transductionc-akt proteinconstrictiondeath among neonatesdeath among newbornsdeath in neonatesdeath in newborndegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesextracellularfetalfetus deathfolate carrierfolate receptorfolate supplementationfolate-binding proteinfolate-methotrexate transporterfolic acid binding proteinfolic acid receptorfolic acid supplementfolic acid supplementationfollow upfollow-upfollowed upfollowupgain of functiongene manipulationgenetic manipulationgenetically manipulategenetically perturbhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimagingin uteroinduced human pluripotent stem cellsliquid chromatography mass spectrometryloss of functionmalignancymechanicmechanicalmembrane structuremethotrexate-binding proteinmolecular profilemolecular signaturemortality among neonatesmortality among newbornsmortality in neonatesmortality in newbornsnamenamednamingneonatal deathneonatal demiseneoplasm/cancernervous system developmentneuralneural modelneural plateneurodegenerative illnessneurogenesisnewborn childnewborn childrennewborn deathnewborn mortalitynoveloptogeneticspharmacologicplasmalemmapreventpreventingprogramsprohibitinproto-oncogene protein RACproto-oncogene protein aktrac protein kinaserecruitrelated to A and C-proteinscaffoldscaffoldingscreeningscreeningssocial rolesupplementation with folatesupplementation with folic acidtherapeutic agent developmenttherapeutic developmenttissue degenerationtranscriptome sequencingtranscriptomic sequencingvitamin Bc
Description preview
Abstract
Supplementation with the vitamin B9, folate, during pregnancy reduces the incidence of neural tube defects
(NTDs), one of the most common and serious birth defects diagnosed in human fetuses and newborns. NTDs
result from the failure of neural tube closure during early fetal development, which potentially exposes the neural
tissue to a…
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