grant

Mechanisms of evolution at the host-pathogen interface

Organization UNIVERSITY OF OREGONLocation EUGENE, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AnimalsAreaAwardBacterial GenomeBacterial InfectionsBindingBiochemistryBiological ChemistryCause of DeathCell Surface ReceptorsCellular biologyCommunicable DiseasesDiathesisDiseaseDisease susceptibilityDisorderEnzyme GeneEnzymesEvolutionFutureGene ConversionGene DuplicationGene variantGenesGeneticGenetic DiversityGenetic VariationHumanImmune EvasionInfectious DiseasesInfectious DisorderInvestigationLaboratoriesMethodsMicrobiologyModern ManMolecularMolecular GeneticsMolecular InteractionNatural SelectionsNutrientPhenotypePhylogenetic AnalysisPhylogeneticsPopulationProcessReceptor ProteinResearchShapesSourceSystemTestingVirulenceWorkallelic variantanti-microbialanti-microbial resistant infectionantimicrobialantimicrobial resistant infectionbacteria infectionbacteria pathogenbacterial diseasebacterial pathogencell biologycombinatorialcomparativegenetic approachgenetic strategygenetic variantgenomic datagenomic datasetgenomic varianthost-pathogen coevolutionhost-pathogen evolutionhuman pathogenimmune evasiveliability to diseasepathogenpathogen-host coevolutionpathogenic bacteriapressureprogramsprotein functionreceptor
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PROJECT SUMMARY
Pathogens and their hosts impose strong selective pressure on one another, leading to the rapid
evolution of host-pathogen molecular interactions. This process in turn can shape pathogen host range,
virulence, and the emergence or reemergence of infectious diseases in human populations. These
features also make host-pathogen…

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Mechanisms of evolution at the host-pathogen interface — UNIVERSITY OF OREGON | UNITED STATES | Aug 2025 | Dev Procure