grant

Mechanisms of Developmental Myelination

Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 15 May 2021Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202621+ years oldAcquired brain injuryAdultAdult HumanAnimalsAreaAxonBiologic ModelsBiological ModelsBrachydanio rerioBrainBrain InjuriesBrain Nervous SystemCNS Nervous SystemCell BodyCell DifferentiationCell Differentiation processCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationCentral Nervous SystemCharacteristicsDanio rerioDataDevelopmentDiseaseDisorderEncephalonFoundationsGeneralized GrowthGeneticGliaGlial CellsGoalsGrowthHortega cellImageImmuneImmunesInjuryInvestigationKolliker's reticulumLearningMembraneMemoryMental disordersMental health disordersMessenger RNAMicrogliaModel SystemMolecularMotorMyelinMyelin SheathNerve CellsNerve UnitNeural CellNeural Stem CellNeuraxisNeurocyteNeurogliaNeuroglial CellsNeuronsNon-neuronal cellNonneuronal cellOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellProteolipidsPsychiatric DiseasePsychiatric DisorderResearchTestingTherapeuticTissue GrowthZebra DanioZebra FishZebrafishadulthoodbrain damagebrain-injuredcell behaviorcellular behaviorcellular differentiationdesigndesigningdevelopmentalgitter cellimaginginjuriesinsightmRNAmembrane structuremental illnessmesogliamicroglial cellmicrogliocytemigrationmyelinationnerve cementnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitoroligodendrocyte differentiationoligodendrocyte precursoroligodendrocyte precursor celloligodendrocyte progenitoroligodendrocyte stem cellontogenyperivascular glial cellpharmacologicprogenitor and neural stem cellsprogenitor cell fate specificationprogenitor fate specificationprogenitor specificationprogramspsychiatric illnesspsychological disorderresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstem cell fate specificationstem cell specification
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PROJECT SUMMARY
The long-term goal of this research program is to understand how specific axons of the developing central

nervous system (CNS) are ensheathed with specific amounts of myelin, a specialized, proteolipid-rich

membrane produced by oligodendroglia. During development, subpopulations of neural progenitors produce

oligodendrocyte…

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Mechanisms of Developmental Myelination — UNIVERSITY OF COLORADO DENVER | UNITED STATES | May 2021 | Dev Procure