grant
Mechanisms of Dcc Receptor Signaling in Neuronal Morphogenesis
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 3 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026ActinsAnimalsAssayAxonBasal Transcription FactorBasal transcription factor genesBilateralBindingBioassayBiochemicalBiological AssayBody TissuesCRC18Cell Communication and SignalingCell NucleusCell SignalingCellular MatrixColorectal Cancer-Related Chromosome Sequence 18ComplexCorpus CallosumCorpus CallosumsCuesCytoskeletal SystemCytoskeletonDCC geneDNA Binding DomainDNA-Binding Protein MotifsDataDeleted in Colorectal CarcinomaDendritesDevelopmentDiseaseDisorderDissectionDrosophilaDrosophila genusDyskinesia SyndromesEmbryoEmbryonicEventFRAsFamilyFliesFos-Related AntigensFoundationsFutureGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionHumanInjuryIntracellular Communication and SignalingInvertebrataInvertebratesKnowledgeL-SerineL-ThreonineLigandsMediatingModern ManMolecularMolecular InteractionMorphogenesisMotorMovementMovement Disorder SyndromesMovement DisordersNerve CellsNerve RegenerationNerve UnitNervous SystemNervous System DiseasesNervous System DisorderNeural CellNeuro-regenerationNeurocyteNeurologic Body SystemNeurologic DisordersNeurologic Organ SystemNeurological DisordersNeuronsNeuroregenerationNucleusOrthologOrthologous GeneOutputPathogenicityPathologicPathway interactionsPhosphatasesPhosphatesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPhosphorylationPlayProcessProtein PhosphorylationProteinsProteomicsRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor ProteinReceptor SignalingRegulationResearchRoleSensorySerineSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSiteTherapeuticThreonineTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationVariantVariationVertebrate AnimalsVertebratesWorkaxon growthaxon growth cone guidanceaxon guidanceaxonal growthbiological signal transductionbody movementcell fate specificationdefined contributiondeleted in colorectal cancerdevelopmentaldevelopmental diseasedevelopmental disorderexperimentexperimental researchexperimental studyexperimentsextracellularflyfruit flygain of functiongaze palsyhorizontal gazein silicoin vivoinjuriesinorganic phosphateinsightintracellular skeletonloss of functionmorphogenetic processmotor behaviornervous system regenerationneuralneural regenerationneurological diseaseneuronalneuroregenerativenovelpathwayprematureprematuritypreventpreventingreceptorrecruitregenerated nerverepairrepairedresponsesocial roletranscription factortranscriptome sequencingtranscriptomic sequencingvertebrata
Description preview
PROJECT SUMMARY
Determining how neurons are assembled into functional circuits will provide insight into developmental
disorders of the nervous system and may suggest therapeutic approaches to promote nerve regeneration. To
navigate to their correct targets, axons must precisely modulate their responses to extracellular cues. For
example, to cross…
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