grant
Mechanisms of Complement Activation in Traumatic Injury
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 15 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Acquired brain injuryAcuteAgeAlteplaseAnimalsAntibodiesAntigensAssayAwardBindingBioassayBiological AssayBiological MarkersBleedingBlood CirculationBlood Coagulation DisordersBlood PlasmaBloodstreamBrain InjuriesBypassCause of DeathCell CoatCell Culture TechniquesCessation of lifeCirculationCirculatory CollapseClinicalClinical ResearchClinical StudyClottingCoagulationCoagulation DisorderCoagulation ProcessCoagulopathyComplementComplement ActivationComplement ProteinsCoupledDataDeathDevelopmentDrynessEndothelial CellsEndotheliumEsteroproteasesExperimental DesignsFibrinolysesFibrinolysinFibrinolysisFoundationsFutureGenerationsGlu-PlasminGlycansGlycobiologyGlycocalyxGoalsHemorrhageHemorrhagic ShockHospitalsHumanImmune systemImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInfectionInflammationInflammatoryInflammatory ResponseInjuryInvestigationIschemiaKO miceKidneyKidney Urinary SystemKnock-out MiceKnockout MiceKnowledgeLectinLifeLinkLiteratureLungLung Respiratory SystemLung damageMannan-Binding LectinMannan-Binding ProteinMannose Binding LectinMannose-Binding ProteinMannose-Specific LectinMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMediatingMedicineMentorsMentorshipMethodologyMiceMice MammalsModelingModern ManMolecularMolecular InteractionMultiple InjuriesMultiple TraumaMurineMusNull MouseOrgan failureOutcomePathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPeptidasesPeptide HydrolasesPlasmaPlasma SerumPlasminPolysaccharidesProcessProtease FProtease GeneProteasesProteinasesProteinsProteolytic EnzymesRecombinant Tissue Plasminogen ActivatorResearchReticuloendothelial System, Serum, PlasmaRoleSamplingScientistSeriesShockSignal PathwaySpecificityStimulusSurgeonSystemT-Plasminogen ActivatorTestingTherapeuticTissue Activator D-44Tissue Plasminogen ActivatorTissue-Type Plasminogen ActivatorTraumaTrauma patientTraumatic ShockTraumatic injuryUnited StatesVascular EndotheliumWild Type MouseWorkagesbio-markersbiologic markerbiomarkerbleeding disorderblood lossbrain damagebrain-injuredcareercell culturecell culturescirculatory shockclotting disordercomplement pathwaycomplement pathway regulationcomplement systemcomplementationcostcritical injurydevastating injurydevelopmentalexposed human populationfightinghemodynamicshuman exposurehypoperfusionimmunogenimprovedimproved outcomeindexinginjuriesinjury responseinjury to organsinnovateinnovationinnovativelung injurymicrobialmodel designmortalitymouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachorgan injurypathwaypatient oriented outcomespolytraumapreventpreventingprogramspulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrandomized, clinical trialsrenalresponseresponse to injurysevere injuryshocksskill acquisitionskill developmentskillssocial rolet-PAtherapeutic targettrauma induced coagulopathytraumatic coagulopathywildtype mouse
Description preview
Project Summary
The leading cause of death from ages 1-44 years in the United States is traumatic injury, responsible for
millions of hospital encounters at a cost of over $4 trillion annually. Unfortunately, outcomes in trauma patients
who survive the initial injury have not seen the marked improvements observed in other fields of medicine…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click