grant
Mechanisms of Circadian Clock Control of mRNA Translation
Organization TEXAS A&M UNIVERSITYLocation COLLEGE STATION, UNITED STATESPosted 1 May 2018Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Amino AcidsAmino Acyl T RNA SynthetasesAmino Acyl-tRNA LigasesAmino Acyl-tRNA SynthetasesAminoacyl Transfer RNA SynthetaseAminoacyl-tRNA SynthetaseBindingCancersCardiac DiseasesCardiac DisordersCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular Metabolic ProcessCellular PhysiologyCellular ProcessChaperoneChargeCircadian RhythmsCyclicityDefectDiseaseDisorderDrug TherapyDrugsEIF-2 alphaEIF-2alphaEIF-2αEukaryotaEukaryoteGenomeHealthHeart DiseasesHumanIntermediary MetabolismKinasesMalignant NeoplasmsMalignant TumorMedicationMessenger RNAMet-tRNA LigaseMetabolic ProcessesMetabolic syndromeMetabolismMethionineMethionine-tRNA LigaseMethionyl T RNA SynthetaseMethionyl-tRNA SynthetaseModelingModern ManMolecular ChaperonesMolecular InteractionNeurospora crassaNyctohemeral RhythmPeriodicityPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhosphorylationPhosphotransferase GenePhosphotransferasesProbabilityProductionProtein BiosynthesisProtein PhosphorylationProteinsProteomeRegulationRegulatory PathwayRhythmicityRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomal ProteinsRibosomesSleep DisordersStop CodonSubcellular ProcessTermination CodonTerminator CodonTestingTimeTransfer RNATransfer RNA AcylationTransfer RNA Amino AcylationTransfer RNA AminoacylationTransfer RNA ChargingTransfer RNA SynthetaseTranslatingTranslation InitiationTranslation Stop SignalTranslationsTransphosphorylasesTriplet Codon-Amino Acid AdaptorTwenty-Four Hour RhythmWorkalpha Subunit Eukaryotic Initiation Factor 2aminoacidaminoacid tRNA ligasecell metabolismcellular metabaolismcircadian clockcircadian pacemakercircadian processcircadian regulationcircadian rhythmicitydaily biorhythmdrug interventiondrug metabolismdrug treatmentdrug/agentheart disorderimprovedinsightmRNAmRNA Translationmalignancyneoplasm/cancernew approachesnovel approachesnovel strategiesnovel strategypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprotein foldingprotein synthesissleep diseasessleep dysfunctionsleep illnesssleep problemtRNAtRNA AcylationtRNA Amino AcylationtRNA AminoacylationtRNA ChargingtRNA Synthetasetransfer Ribonucleic acidstranslation
Description preview
Summary
The circadian clock, critical to human health and drug metabolism, regulates rhythmic protein production
and thus cell function and metabolism. Many proteins whose levels show robust circadian rhythms are produced
from mRNAs that are not rhythmic. Using the model eukaryote Neurospora crassa, we found that up to half of
this circadian…
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