grant
Mechanisms of cell fate specification and competence regulation in photoreceptors
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Apr 2014Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20253-D3-D structure3-Dimensional3-dimensional structure3C-based approach3C-based assay3C-based method3C-based strategy3C-based technique3C-based technology3D3D structureAge related macular degenerationAge-Related MaculopathyAmericanAntimorphic mutationArchitectureBasal Transcription FactorBasal transcription factor genesBlindnessCRISPRCRISPR approachCRISPR based approachCRISPR interferenceCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR-dCas9-mediated repressionCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCas nuclease technologyCell BodyCell CycleCell Division CycleCell Fate ControlCell Fate RegulationCellsClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats interferenceClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCompensationCompetenceConeCone PhotoreceptorsConnector NeuronDNADataDeoxyribonucleic AcidDevelopmentDiminished VisionDiseaseDisorderDominant NegativeDominant-Negative MutantDominant-Negative MutationEngineering / ArchitectureEnhancer ElementsEnhancersEquilibriumEventFaceFunctional RNAGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic Enhancer ElementGenetics-MutagenesisGenomeGoalsHumanImpairmentIndividualIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInvestigatorsKnowledgeLow VisionMethodsMiceMice MammalsModern ManMolecularMultipotent Stem CellsMurineMusMutagenesisMutagenesis Molecular BiologyMutant Strains MiceMutateNatural regenerationNerve CellsNerve UnitNeural CellNeurocyteNeuronsNoncoding RNANontranslated RNAOther GeneticsPartial SightPersonsPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiologic pulsePopulationProgenitor CellsPulseReduced VisionRegenerationRegulationRegulatory ElementResearch PersonnelResearchersResolutionRetinaRetinal ConeRetinal DiseasesRetinal DisorderRodRods and ConesSourceSubnormal VisionTestingTherapeuticTimeTranscription Factor Proto-OncogeneTranscription factor genesTransplantationUndifferentiatedUntranslated RNAVertebrate PhotoreceptorsVisual ReceptorVisual impairmentage dependent macular degenerationage induced macular degenerationage related macular diseaseage related macular dystrophybalancebalance functioncell fate specificationcell typechromatin conformation capturechromosome capturechromosome conformation capturecone celldevelopmentalenhancer sequenceexperimentexperimental researchexperimental studyexperimentsfacesfacialgene regulatory networkgenetic approachgenetic enhancer sequencegenetic strategyloss of functionmouse mutantmultipotencymultipotentmultipotent progenitormultipotent progenitor cellmutantneuronalnoncodingpreventpreventingprogenitorpromoterpromotorregenerateregeneration based therapyregeneration therapyregenerative approachregenerative strategyregenerative techniqueregenerative therapeuticsregenerative therapyrepressing CRISPR-dCas9 systemresolutionsrestore sightrestore visionretina diseaseretina disorderretinal progenitorretinal progenitor cellretinal stem cellretinopathysenile macular diseasesight restorationstem cellsthree dimensionalthree dimensional structuretooltranscription factortransplantvision impairmentvision lossvision restorationvisual lossvisually impaired
Description preview
PROJECT SUMMARY:
Age-related macular degeneration and several other diseases can cause rod and cone photoreceptors to
die. This results in permanent visual impairment because the human retina does not regenerate itself. One
potential way to restore vision is by replacing the lost photoreceptors. Audacious strategies to restore vision
include…
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