grant
Mechanisms of Bacterial Lysis Sensing
Organization CARNEGIE-MELLON UNIVERSITYLocation PITTSBURGH, UNITED STATESPosted 12 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025Active Follow-upAntibiotic TherapyAntibiotic TreatmentAutomationBacteriaBacteriophagesBehaviorBiochemicalBiochemistryBiocontrolsBiological ChemistryBionomicsCell Communication and SignalingCell ProtectionCell SignalingCell SurvivalCell ViabilityCessation of lifeClinicalCommunitiesComplexCytolysisCytoprotectionDeathDefense MechanismsDevelopmentDiseaseDisorderEcologyEncapsulatedEnvironmentGoalsHealthImmune systemIndustrializationIntracellular Communication and SignalingLaboratoriesLife CycleLife Cycle StagesLysisMicrobial BiofilmsMicrobiologyMicroscopyMolecularPathway interactionsPhagesPhagocytosisPopulationProcessReceptor ProteinReceptor SignalingRegulationResearchSightSignal TransductionSignal Transduction SystemsSignalingStructureTherapeuticV choleraeV. choleraeVibrio choleraeVibrio commaVisionWorkactive followupbacterial communitybacterial disease treatmentbacterial infectious disease treatmentbacterial virusbiofilmbiological signal transductioncell communitycellular communityclinical relevanceclinically relevantcytoprotectivedevelopmentalfollow upfollow-upfollowed upfollowupimaging approachimaging based approachinterdisciplinary approachlife coursemicrobialmicrobiomemultidisciplinary approachnovelpathwayprogramspsychological defense mechanismreceptorresponsevisual function
Description preview
PROJECT SUMMARY
Matrix-encapsulated communities of bacteria, called biofilms, are ubiquitous in the environment and are
notoriously difficult to eliminate in clinical and industrial settings. Existing within biofilms offers resident
cells protection from threats, such as bacteriophage attacks, phagocytosis by the host immune system,
and antibiotic…
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