grant

Mechanisms of autoimmune dysregulation in lipoic acid users at risk for NELL1 membranous nephropathy

Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 26 Jul 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20251,2-Dithiolane-3-pentanoic acid21+ years oldAddressAdultAdult HumanAffectAnthelone UAntibodiesAntibody ResponseAntigensAutoimmuneAutoimmune DiseasesAutoimmune MechanismAutoimmune ProcessAutoimmune ResponsesAutoimmune StatusAutoimmunityB blood cellsB cellB cell depletion therapyB cell directed therapyB cell targeted therapyB cell therapiesB cell therapyB cellsB-CellsB-LymphocytesB-cellBiological MarkersBloodBlood ClottingBlood Reticuloendothelial SystemBlood SerumBlood coagulationCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCellsCharacteristicsClinicalComputerized Medical RecordCounselingDataDiffuseDiseaseDisease remissionDisorderDropsyDrug ExposureDrugsDyslipidemiasEC 3.1.1.4ESKDESRDEarly DiagnosisEarly identificationEdemaElectronic Medical RecordEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEnvironmental FactorEnvironmental Risk FactorEpidermal Growth FactorEpidermal Growth Factor-UrogastroneExtramembranous GlomerulopathyFc ReceptorFeasibility StudiesFemaleFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoundationsFundingFutureGoalsHydropsImmuneImmune MarkersImmune ToleranceImmunesImmunoblottingImmunochemical ImmunologicImmunologicImmunologic MarkersImmunologic ToleranceImmunologicalImmunologicallyImmunologicsInflammatoryInstitutionInvestigationK-AwardsK-Series Research Career ProgramsKidneyKidney DiseasesKidney FailureKidney InsufficiencyKidney Urinary SystemKnowledgeLeadLeadershipLecithinase A2Lipoic AcidLong-term cohortLongitudinal StudiesLongitudinal cohortManuscriptsMarketingMeasuresMediatingMedicalMedical ResearchMedicationMembranous GlomerulonephritisMembranous GlomerulonephropathyMembranous GlomerulopathyMembranous NephropathyMentorsMentorshipMercaptansMercapto CompoundsNephropathyNeuropathyObservation researchObservation studyObservational StudyObservational researchOregonOrphan DiseasePBMCPLA2PathogenicityPatientsPb elementPeripheralPeripheral Blood Mononuclear CellPersonsPharmaceutical PreparationsPhenotypePhospholipase A2PlayPopulationPredispositionPrevalenceProteinsProteinuriaRare DiseasesRare DisorderReceptor ProteinRegulatory T-LymphocyteRemissionRenal DiseaseRenal FailureRenal InsufficiencyReportingResearchResearch Career ProgramResearch ResourcesResourcesRiskRisk FactorsRoleScienceSerumSpainSpecific qualifier valueSpecifiedSulfhydryl CompoundsSusceptibilitySwellingT cell responseT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTestingThioctic AcidThiolsThrombosisTrainingTregUrineUrogastroneVisceral Epithelial CellWestern BlottingWestern ImmunoblottingWomanadulthoodalpha-Lipoic Acidantibody receptorautoimmune conditionautoimmune disorderautoimmune kidney diseaseautoimmune kidney injuryautoimmune renal diseaseautoimmune renal injuryautoimmunity diseasebeta-Urogastronebio-markersbiologic markerbiomarkerchronic painclinical riskcytokinedesigndesigningdiet supplementdietary supplementsdrug/agentearly biomarkersearly detectionearly detection biomarkersearly detection markersenvironmental riskexperienceflow cytophotometryglomerular visceral epithelial cellheavy metal Pbheavy metal leadhigh riskimmune system toleranceimmune unresponsivenessimmune-based biomarkersimmunogenimmunological biomarkersimmunological markersimmunological paralysiskidney disorderlecithinase Along-term studylongitudinal outcome studiesneuralneuropathicnovelnutritional supplementorphan disorderpathogenperipheral bloodphosphatidasephosphatidolipasephosphatidylcholine 2 acylhydrolasepodocytepre-clinicalpreclinicalpreventpreventingprotein blottingreceptorrecruitregulatory T-cellsrenalrenal disordersexsocial rolesulfhydryl grouptargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthrombotic diseasethrombotic disorderthymus derived lymphocytetranslational investigatortranslational researchertranslational scientist♀
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Project Summary/Abstract
We identified an association between lipoic acid and neural epidermal growth-factor like 1 (NELL1)
membranous nephropathy (MN), an autoimmune kidney disease that causes urine protein loss (proteinuria),
diffuse body swelling, and blood clots. If the condition is not detected early, NELL1 MN can lead to kidney
failure.…

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Mechanisms of autoimmune dysregulation in lipoic acid users at risk for NELL1 membranous nephropathy — OREGON HEALTH & S | Dev Procure