grant
Mechanisms of aryl hydrocarbon receptor control of eosinophilic esophagitis
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 15 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20252,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors3-D3-Dimensional3DAH ReceptorsAgonistAirAllergicAllergic DiseaseAllergyAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntigensAntiproteasesAreaAryl Hydrocarbon ReceptorAutoregulationBasal Transcription FactorBasal transcription factor genesBiologyBody TissuesCell BodyCell Communication and SignalingCell LineCell NucleusCell SignalingCellLineCellsDataDependenceDevelopmentDietDifferentiated GeneDioxin ReceptorsDiseaseDisorderEndopeptidase InhibitorsEnvironmentEnvironmental FactorEnvironmental Risk FactorEnzyme GeneEnzymesEosinophiliaEosinophilic EsophagitisEpithelial CellsEpitheliumEquilibriumEsophageal DiseasesEsophageal DisorderEsophagusExposure toFoodGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenetic TranscriptionHealthHomeostasisHumanImmuneImmunesImmunityInflammationInflammatory ResponseInnate Immune ResponseInterventionIntracellular Communication and SignalingL-TryptophanLevotryptophanLife StyleLifestyleLigandsMediatingMiceMice MammalsModelingModern ManMolecularMurineMusNatureNuclear TranslocatorNucleusOutcomeOxazoloneParticulate MatterPathogenesisPathologyPathway interactionsPenetrationPeptidase InhibitorsPeptide Hydrolase InhibitorsPeptide Peptidohydrolase InhibitorsPhysiological HomeostasisPlayPolyaromatic Hydrocarbon ReceptorsPrevalenceProbioticsProcessProductionProtease AntagonistsProtease InhibitorProteinase InhibitorsProton Pump InhibitorsRNA ExpressionReactionReceptor ActivationReceptor ProteinReceptor SignalingResearchRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSourceStimulusStrains Cell LinesStratified EpitheliumTCDD ReceptorsTestingTissuesTranscriptionTranscription ActivationTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ActivationTryptophanTryptophan MetabolismTryptophan Metabolism PathwayXenobioticsZincZinc decreasedZinc deficiencyZinc lowZn deficiencyZn elementZn levels lowZn++ lowahr ligandallergen responseallergic responseallergy responsearyl hydrocarbon receptor ligandbalancebalance functionbiological signal transductionconditional knock-outconditional knockoutcultured cell linedevelopmentaldietarydietsdiseases of esophagusenvironmental riskesophagus disorderimmunogenin vivoinsightlow Zinc levelmicrobiomemicrobiota derived metabolitesmicrobiota metabolitesmouse modelmurine modelpathwaypharmacologicreceptorresponsesensorsocial rolethree dimensionaltoxicanttranscription factor
Description preview
PROJECT SUMMRAY
Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus partially mediated by epithelial barrier
breach, resulting in harmless antigens penetrating the underlying tissues, encountering immune cells, and
triggering allergic responses. The surge in allergy prevalence is often attributed to shifts in environmental…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click