grant
Mechanisms of Antibody-Dependent Enhancement of Dengue Disease
Organization ROCKEFELLER UNIVERSITYLocation NEW YORK, UNITED STATESPosted 24 Sept 2018Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20250-4 weeks old7S Gamma GlobulinAffinityAntibodiesAntibody RepertoireAntibody-Dependent EnhancementAntigenic SpecificityAreaAutoimmune StatusAutoimmunityAutomobile DrivingBiologicalBlood SerumBlood leukocyteBreakbone Fever VirusCOVID-19CV-19CambodiaCellular AssayChemotactic CytokinesClinicalComplexCoronavirus Infectious Disease 2019CoupledDENVDENV infectionDengueDengue Hemorrhagic FeverDengue InfectionDengue Shock SyndromeDengue VirusDengue fever virusDengue virus infectionDevelopmentDiathesisDiseaseDisease susceptibilityDisorderEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEventExhibitsFc domainFundingGeneral Prognostic FactorGlycansHeterogeneityHigh PrevalenceHistoryHomologous Chemotactic CytokinesHumanIgGImmuneImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunesImmunoglobulin GImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionIn VitroInfectionInflammatoryIntercrinesKampucheaKhmer RepublicLeukocytesLeukocytes Reticuloendothelial SystemLifeMacrophageMacrophage ActivationMarrow leukocyteMediatingMemoryModelingModern ManMorbidityMorbidity - disease rateMothersMouse StrainsMyeloid CellsMφNewborn InfantNewbornsOutcomePathogenesisPathogenicityPathway interactionsPatientsPersonsPlasmablastPolysaccharidesPopulationPredispositionPrognostic FactorPrognostic/Survival FactorPublic HealthReceptor ProteinRecording of previous eventsRecurrenceRecurrentRiskRisk FactorsRoleSIS cytokinesSerumSeveritiesSeverity of illnessSpleenSpleen Reticuloendothelial SystemSusceptibilitySymptomsTherapeuticTranscription AlterationVaccinationViral DiseasesVirus DiseasesVirus ReplicationWhite Blood CellsWhite Cellarthropod transmissionarthropod transmittedarthropod-bornearthropodbornebiologiccell assaychemoattractant cytokinechemokinecoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19cytokinedengue viral infectiondevelopmentaldisease severitydrivingepidemiologic investigationepidemiology studyexperienceglobal gene expressionglobal transcription profilehistorieshost responseimmune activationimmune system responseimmunological statusimmunoresponsein vivoin vivo Modelinfection riskinsightliability to diseasemortalitymouse modelmurine modelnewborn childnewborn childrennovelpathogenic viruspathwaypermissivenessreceptorresponsesevere denguesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptomeviral infectionviral multiplicationviral pathogenviral replicationvirus infectionvirus multiplicationvirus pathogenvirus-induced diseasewhite blood cellwhite blood corpuscle
Description preview
ABSTRACT
Instead of conferring protection, IgG antibodies against dengue virus (DENV) have been correlated with
increased susceptibility to symptomatic dengue disease, as patients with pre-existing antibodies against DENV
experience at a higher rate the symptomatic form of dengue disease, which often includes life-threatening
complications. With…
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