grant
Mechanisms Governing Nerve-Mediated Control of Corneal Wound Healing: New Hope for Patients with Neurotrophic Keratopathy
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AblationAffectAmericanAnimal ModelAnimal Models and Related StudiesAxonAxon TerminalsBlindnessBody TissuesBody partCell BodyCell CommunicationCell InteractionCell SurvivalCell ViabilityCell-to-Cell InteractionCellsChronicClinicalCompensationCorneaCorneal InjuryCorneal LimbusCorneal UlcerCorneoscleral JunctionCorneoscleral LimbusDenervationDeteriorationDevelopmentDrugsEpithelial CellsEpitheliumFDA approvedFaceFailureFree Nerve EndingFutureGatekeepingGeneticHealthHumanImpairmentIn VitroIncidenceInfectionInjuryInstitutionInvestigationKeratopathyKnowledgeLegal patentLibrariesLimbus CorneaeMaintenanceMediatingMedicationMiceMice MammalsModelingModern ManMolecularMurineMusNerveNerve CellsNerve Growth FactorsNerve TransferNerve UnitNeural CellNeurilemma CellNeurilemmal CellNeurocyteNeuronotrophic FactorsNeuronsNeurotizationNeurotrophic ProteinsOperative ProceduresOperative Surgical ProceduresPatentsPatientsPersonsPharmaceutical PreparationsPopulationPresynaptic Nerve EndingsPresynaptic TerminalsProceduresProgenitor CellsProtein SecretionRecombinantsRecoveryRegulationReportingResearch ProposalsRodentRodentiaRodents MammalsRoleRunningSchwann CellsSclerocorneal LimbusSensorySightSurgicalSurgical InterventionsSurgical ProcedureSynaptic BoutonsSynaptic TerminalsTherapeuticTissuesTopical Drug AdministrationTopical applicationTraumaUlcerative KeratitisUncertaintyVisionWound Repairafferent nerveapply topicallyblink reflexescandidate identificationcleft lip and palatecleft lip/palatecleft palate/lipclinical practiceclinical translationclinically translatablecornea ulcercornealcorneal epithelialcorneal epithelial wound healingcorneal epitheliumcorneal surgerycorneal ulcerationcorneal woundcorneal wound healingdeliver topicallydevelopmentaldoubtdrug/agentexperimentexperimental researchexperimental studyexperimentseye blink reflexeyeblink reflexfacesfacialgain of functiongatekeeperhealingimprovedimproved outcomein vivoinjuriesinnervationinnovateinnovationinnovativeinsightlimballoss of functionmigrationmodel of animalnerve supplyneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyocular surfaceoperationoperationsoptical blink reflexparacrinepharmacologicprogenitor biologyprogenitor cell biologyprogenitor cell maintenanceprogenitor cell nicheprogenitor cell proliferationprogenitor maintenanceprogenitor nicheprogenitor proliferationreinnervatereinnervationrelease factorscRNA sequencingscRNA-seqsensory mechanismsensory nervesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem and progenitor biologystem and progenitor cell nichestem and progenitor cell proliferationstem cell biologystem cell maintenancestem cell nichestem cell proliferationstem cellssurgerytopical administrationtopical deliverytopical drug applicationtopical drug deliverytopical instillationtopical treatmenttreat topicallytumorvision lossvisual functionvisual losswound healingwound recoverywound resolution
Description preview
PROJECT SUMMARY:
Overview: The molecular mechanisms by which corneal nerves regulate limbal stem cells (LSCs), required for
corneal epithelial maintenance and wound healing, and ultimately critical for vision, are unknown. When corneal
nerves are impaired or absent, patients develop nonhealing corneal wounds that lead to permanent blindness,
a…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click