grant
Mechanisms by which extracellular vesicles released by allografts promote anti-donor immunity
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY20262-photon microscopyAddressAffectAllogenicAllograftingAnti-Rejection TherapyAntigen PresentationAntigen-Presenting CellsAntigensB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBiogenesisBiologyBlood group antigen SBody TissuesCancersCardiac TransplantationCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessChronicCommunicationComputer AnalysisDataDendritic CellsDevelopmentDiseaseDisease MarkerDisorderEndothelial CellsExhibitsFamilyFellowshipGEM modelGEMM modelGenetically Engineered MouseGoalsGraft RejectionGraft SurvivalHeart GraftingHeart TransplantationImmuneImmune Cell ActivationImmune reactionImmune responseImmune systemImmunesImmunityImmunomodulationImmunosuppressantsImmunosuppressionImmunosuppression EffectImmunosuppressive AgentsImmunosuppressive EffectImmunosuppressive TherapyImmunosuppressive drugImmunosuppressive treatmentIn SituInflammation MediatorsInflammatoryInnate Immune ResponseInterventionIntracellular Communication and SignalingKnowledgeLabelLifeLipidsLung GraftingLung TransplantationLymph Node Subcapsular SinusLymphatic TissueLymphoid TissueMHC antigenMacrophageMalignant NeoplasmsMalignant TumorMediatingMediatorMentorshipMiceMice MammalsMurineMusMφNon-Polyadenylated RNAOrganOrigin of LifeParentsPhenotypePhysiciansPlayProductionProliferatingProteinsProteomicsPulmonary GraftPulmonary TransplantPulmonary TransplantationRNARNA Gene ProductsResearchRibonucleic AcidRoleS antigenScientistShapesSignal TransductionSignal Transduction SystemsSignalingSourceStromal CellsSubcapsular SinusSubcellular ProcessT memory cellT-Cell ActivationT-CellsT-LymphocyteTeff cellTestingTherapeutic InterventionTherapeutic immunosuppressionTissuesToxic effectToxicitiesTransgenic MiceTransplant RecipientsTransplant RejectionTransplant immunologyTransplantationTransplantation ImmunologyTransplantation RejectionVeiled CellsVesicleaccessory cellactivate T cellsadaptive immune responseallograft rejectionalloimmunityartificial immunosuppressionbiological signal transductioncardiac allograftcardiac graftcareercell typeclinical relevanceclinically relevantcomputational analysescomputational analysiscomputer analysescytokinedevelopmentaldraining lymph nodeeffector T cellend-stage organ failureexosomeextracellular vesiclesgenetically engineered mouse modelgenetically engineered murine modelglobal gene expressionglobal transcription profileheart allograftheart transplanthorizontal cellhost responseimmune activationimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive agentimmune suppressive functionimmune suppressorimmune system responseimmunogenimmunologic reactivity controlimmunomodulatoryimmunoreactionimmunoregulationimmunoregulatoryimmunoresponseimmunosuppression therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunosuppressive substanceimmunosuppressorimprovedin vivoinfection riskinflammatory mediatorinsightintervention therapyisoimmunitylung transplantmalignancymemory T lymphocytemicrovesiclesmouse modelmurine modelneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetparentregional lymph noderesponseside effectskin allograftsocial rolethymus derived lymphocytetranscriptometranscriptomicstransplanttransplant modeltransplant patienttwo photon excitation microscopytwo photon microscopyvesicle releasevesicular release
Description preview
PROJECT SUMMARY/ABSTRACT
This proposal aims to unveil the mechanisms by which graft-derived extracellular vesicles (EVs), carrying donor
antigens (Ags) and immunoregulatory mediators, initiate the innate and adaptive immune responses that cause
rejection of allografts. Transplant rejection remains a critical barrier to long-term graft survival,…
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