grant
Mechanisms and Regulations of kappa Opioid Receptor Signaling
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 15 Jun 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026ADRBK1ADRBK1 geneAddressAffectAffective DisordersArrestinsAssayBARK1Beta-ARK-1BindingBioassayBiological AssayBiologyBreast Cell GlutaminaseCause of DeathCell Communication and SignalingCell SignalingCessation of lifeChemicalsClinicalComplexCoupledCouplingDataDeathDevelopmentDrugsEC 3.5.1.2EffectivenessEventG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG Protein-Coupled Receptor Kinase 5G-Protein-Coupled ReceptorsG-ProteinsGA ProteinGPCRGPRK5GPRK5 GeneGRK2GRK5GRK5 geneGTPGTP-Binding ProteinsGTP-Regulatory ProteinsGenetics-MutagenesisGlutaminaseGoalsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsGuanosine TriphosphateIndividualIntracellular Communication and SignalingKinasesKineticsL glutamine amidohydrolaseLabelLigandsLiver GlutaminaseMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMediatorMedicationMolecularMolecular Dynamics SimulationMolecular InteractionMood DisordersMutagenesisMutagenesis Molecular BiologyOpiate ReceptorsOpiatesOpioidOpioid ReceptorOutcomePainPain ControlPain TherapyPain managementPainfulPathway interactionsPharmaceutical PreparationsPharmacologyPhosphorylationPhosphotransferase GenePhosphotransferasesPlayProtein PhosphorylationProteinsReceptor ActivationReceptor ProteinReceptor SignalingRegulationReportingRespiratory DepressionRetinal S-AntigenRiskRoleRouteSeriesSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinStructureTestingTherapeuticTimeTransducersTransphosphorylasesTreatment EfficacyVentilatory Depressionabuse liabilityabuse potentialaddictionaddictive disorderalternative treatmentarrestin Bbehavior responsebehavioral responsebeta-arrestinbiological signal transductiondepressed breathingdepression of breathingdesigndesigningdevelopmentaldrug/agentinsightintervention efficacykappa opiatekappa opioidkappa opioid receptorsmolecular dynamicsmu opioid receptorsnovelopiate overdoseopiate related overdoseopioid drug overdoseopioid induced overdoseopioid intoxicationopioid medication overdoseopioid overdoseopioid poisoningopioid related overdoseopioid toxicitypain interventionpain reliefpain treatmentpathwayprotein functionprotein protein interactionradioligandreceptorreceptor internalizationrecruitrelieve painresponseside effectsocial rolespatial and temporalspatial temporalspatiotemporalstructural determinantsstructural factorstherapeutic efficacytherapeutic targettherapy efficacytoolβ-arrestinκ opiateκ opioidκ opioid receptorsκ-ORκORμ opioid receptorsμ-ORμOR
Description preview
Opiates have been widely prescribed for pain management in the US, with a staggering 142 million prescriptions
in 2020 alone. While these drugs effectively relieve pain by interacting with the mu opioid receptor (MOR), their
complex pharmacology has led to concerning side effects such as abuse potential, respiratory depression, and
addiction…
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