grant
Mechanisms and Impact of NRG3 Induction in Bone Metastasis
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 24 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAreaAutocrine SystemsAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBindingBlood VesselsBone MetastasisBone cancer metastaticBony metastasisBrainBrain Nervous SystemBreast CancerBreast Cancer ModelBreast Cancer PatientBreast Cancer TreatmentBreast MetastasisBreast Tumor PatientBreast tumor modelCell BodyCell Communication and SignalingCell CountCell NumberCell SignalingCell SurvivalCell ViabilityCellsClinicalClinical ResearchClinical StudyCo-cultureCocultivationCocultureCoculture TechniquesCollecting CellCoupledCuesDON-1DON1DiagnosisDiseaseDisorderDistantEGFEGF geneENX-1EZH1EZH2EZH2 geneEcologic SystemsEcological SystemsEcosystemEncephalonEndocrineEnhancer of Zeste 2 Polycomb Repressive Complex 2 SubunitEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitheliumEstrogen ReceptorsFGF ReceptorsFGF-RFGFRFamilyFibroblast Growth Factor Receptor FamilyFibroblast Growth Factor ReceptorsGGFGGF2General Transcription Factor GeneGeneral Transcription FactorsGoalsGrowth Factor ReceptorsHGLHR positiveHRGAHeregulin GeneHeterodimerizationImmunofluorescenceImmunofluorescence ImmunologicIn VitroIndividualInjectionsIntracellular Communication and SignalingInvestigationKMT6KMT6ALesionLigand BindingLigandsMICMETMalignant Breast NeoplasmMalignant CellMediatingMediatorMetastasisMetastasis to boneMetastasizeMetastatic Cancer to the BoneMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the BoneMetastatic TumorMetastatic Tumor to the BoneMetastatic breast cancerMetastatic malignant neoplasm to boneMicrometastasisMicrometsModelingMolecularMolecular InteractionMutateNEU Differentiation Factor GeneNRG ProteinsNRG1NRG1 geneNRG2NRG2 geneNRG3NRG3 geneNTAKNeoplasm Circulating CellsNeoplasm MetastasisNeu-Differentiation FactorNeuregulin 3NeuregulinsNon-Polyadenylated RNAOrganOsseous metastasisOsteoblastsOsteoclastsPTK ReceptorsPrimary NeoplasmPrimary TumorProcessPropertyRNARNA Gene ProductsReceptor ProteinReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneRecoveryResistanceRibonucleic AcidRoleSchizophreniaSchizophrenic DisordersSecondary NeoplasmSecondary TumorSecondary cancer of boneSecondary malignancy of boneSecondary malignant neoplasm of boneSecondary toSensory-and-motor-derived factorSignal TransductionSignal Transduction SystemsSignalingSiteSkeletal metastasisSpectrophotometryStem Cell likeTNBCTestingTherapeuticTranscription Factor Proto-OncogeneTranscription factor genesTransmembrane Receptor Protein Tyrosine KinaseTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsVisceralVisceral metastasisautocrinebiological signal transductionbonebone neoplasm secondarybreast cancer metastasiscancer cellcancer metastasiscancer microenvironmentcancer progressioncancer sub-typescancer subtypescirculating neoplastic cellcirculating tumor cellclinical investigationdementia praecoxdrivingepigeneticallygenetic approachgenetic strategyhormone receptor +hormone receptor-positiveiliac arteryimaging approachimaging based approachin vivoindividuals with breast cancermalignant breast tumormammary cancer modelmammary tumor modelmembermetastatic breast tumormetastatic mammary cancermetastatic mammary tumorneoplasm progressionneoplastic progressionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpatients with breast cancerperson with breast cancerpre-clinical studypreclinical studyprogenitor capacityprogenitor cell likeprogenitor-likepromoterpromotorreceptorresistance mechanismresistance to therapyresistantresistant mechanismresistant to therapyschizophrenicshRNAshort hairpin RNAskeletal tissuesmall hairpin RNAsocial rolespectrophotometerstem cell characteristicsstem-likestemnesstherapeutic resistancetherapy resistantthree dimensionaltranscription factortranscriptomicstreatment resistancetriple-negative breast cancertriple-negative invasive breast carcinomatumortumor cell metastasistumor microenvironmenttumor progressionvascular
Description preview
Without the occurrence of cancer cell dissemination (metastasis), most breast cancer patients would
survive following diagnosis and treatment. Alas, cancer cells can disseminate to distant sites long
before diagnosis of the primary tumor. Based on clinical investigations, bone is established as the most
predominant site of metastasis in breast…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click