grant
Mechanisms and Functions of Cortical Activity to Restore Behavior
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025Acquired brain injuryAffectAnesthesiaAnesthesia proceduresAnesthestic DrugsAnesthetic AgentsAnesthetic DrugsAnestheticsAnimalsAnteriorAreaArousalAssayAuditoryAutomobile DrivingAwarenessBehaviorBehavioralBioassayBiological AssayBiological MarkersBrainBrain InjuriesBrain Nervous SystemBrain StemBrainstemCOVID survivorsCOVID-19 infection survivorsCOVID-19 survivorsCell Communication and SignalingCell NucleusCell SignalingComaComa hyperglycemicComatoseConsciousConsciousnessConsciousness DisordersCuesDecerebration procedureDeglutitionDiabetic ComaDoppler UltrasoundEchographyEchotomographyEncephalonExhibitsFaceFore-BrainForebrainGoalsHeadHourHydrogen OxideImageIndividualInhalationInhalingInjuryIntracellular Communication and SignalingKnowledgeLearningLinkLipLip structureLocomotor ActivityMapsMeasurementMeasuresMediatingMedicalMedical UltrasoundMethodsMiceMice MammalsModelingMonitorMotorMotor ActivityMotor CortexMovementMurineMusNerve CellsNerve UnitNeural CellNeural PathwaysNeurocyteNeuronsNucleusPathologicPathway interactionsPatientsPatternPersonsPopulationPopulation DynamicsPreparationProcessPrognosisProsencephalonPublic HealthQOLQuality of lifeRecoveryReflexReflex actionReportingRodentRodentiaRodents MammalsSARS-CoV-2 survivorsSi elementSignal TransductionSignal Transduction SystemsSignalingSiliconStimulusSwallowingSystemTechniquesTimeTouchTouch sensationUltrasonic ImagingUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestUnconsciousUnconscious StateUnconsciousnessWakefulnessWaterWorkauditory stimulusbasal forebrainbehavior responsebehavioral responsebio-markersbiologic markerbiological signal transductionbiomarkerbody movementbrain damagebrain-injuredconsciousness lossdecerebrationdeep learningdeep learning methoddeep learning strategydensitydiagnostic ultrasounddrivingexperimentexperimental researchexperimental studyexperimentsextracellularfacesfacialfrontal cortexfrontal lobegoal oriented behaviorhypoglycemic comaimagingimaging systemimprovedinjuriesinnovateinnovationinnovativekinematic modelkinematicsmotor behaviorneuralneural circuitneural circuitryneural mechanismneurocircuitryneuromechanismneuronalnoveloptogeneticspathwayperceptual stimulusphysicochemical phenomena related to the sensespreparationsrecruitresponserestorationsensory stimulussonogramsonographysoundsound measurementspatial and temporalspatial temporalspatiotemporalsurvive COVID-19survive SARS-CoV-2synaptic circuitsynaptic circuitrytactile sensationtemporal measurementtemporal resolutiontime measurementtongue basetongue rootultrasound imagingultrasound scanning
Description preview
Project Summary
Monitoring the transition to wakefulness is critical during restoration to consciousness after brain injury,
anesthesia, and in those COVID-19 survivors that have altered consciousness. However, we have an imprecise
understanding of neural dynamics linked to behavioral changes as subjects awaken. Our previous work
discovered that…
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