grant
Mechanisms and Consequences of PAX2 Inactivation in the Initiation of Endometrial Carcinogenesis
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 2 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-Kinase21+ years old3-D3-Dimensional3DAccelerationAddressAdultAdult HumanAfrican AmericanAfro AmericanAfroamericanAnimal ModelAnimal Models and Related StudiesArchitectureAreaAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBiologicalBiologyBody TissuesCancer InductionCancer cell lineCancersCell BodyCell CommunicationCell InteractionCell LineCell-to-Cell InteractionCellLineCellsCessation of lifeChIP SequencingChIP-seqChIPseqChromosomal, Gene, or Protein AbnormalityClinicalCre driverCytogenetic or Molecular Genetic AbnormalityDNA mutationDataDeathDevelopmentDiagnosisDisseminated Malignant NeoplasmEarly DiagnosisEmbryologic StructureEmbryonic StructuresEndocrine Gland SecretionEndometrialEndometrial CancerEndometrial CarcinomaEndometrial NeoplasmsEndometrial TumorEndometriumEndometrium CancerEndometrium CarcinomaEndometrium TumorEngineering / ArchitectureEnhancersEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpitheliumEventFundingFutureGene AlterationGene DeletionGene ExpressionGene InactivationGene MutationGene SilencingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic AbnormalityGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGenomicsGlandGoalsGrantGrowthHispanic FemalesHispanic WomenHormonesHumanIncidenceInvestigationInvestigatorsKidneyKidney Urinary SystemLaboratoriesLifeLightLow Molecular Weight Nuclear RNAMMAC1MMAC1 proteinMachine LearningMalignant Neoplasm of the UterusMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the OvaryMalignant Tumor of the UterusMalignant Uterine NeoplasmMalignant Uterine TumorMalignant neoplasm of ovaryMetastatic CancerMetastatic Malignant NeoplasmMethodsMethylationMiceMice MammalsMicroscopyModelingModern ManMolecularMolecular AbnormalityMullerian DuctsMurineMusMutated in Multiple Advanced Cancers 1MutationNeoplasm of the EndometriumOncogenesisOperative ProceduresOperative Surgical ProceduresOrganoidsOvary CancerPHTS genePHTS proteinPI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePTENPTEN genePTEN proteinPTEN1Paramesonephric DuctPathway interactionsPatientsPhosphatase and Tensin HomologPhosphatase and Tensin Homolog Deleted on Chromosome 10Phosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhotoradiationPrevalencePreventionPrimary NeoplasmPrimary TumorProcessProteinsPtdIns 3-KinaseRNA ExpressionRNA SeqRNA sequencingRNAseqRepressionResearchResearch PersonnelResearch SpecimenResearchersRisk FactorsRoleShapesSmall Molecular Weight RNASmall Nuclear RNASpecimenStrains Cell LinesStructure of paramesonephric ductSurgicalSurgical InterventionsSurgical ProcedureTherapeutic HormoneTimeTissue GrowthTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTumor Suppressor ProteinsType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseUterine CancerUterine liningUterusUterus CancerWomanadulthoodadvanced diseaseadvanced illnessanti-cancer researchbiologiccancer progressioncancer researchcarcinogenesischromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcultured cell linedevelopmentaldisparity in caredisparity in health caredrivingearly detectionendometrial neoplasiaepidemiologicepidemiologicalepigeneticallyepigenomicsexperimentexperimental researchexperimental studyexperimentsfrontiergene defectgene deletion mutationgenital tractgenome mutationgenome wide analysisgenome wide studiesgenome-wide analysisgenome-wide identificationhealth care disparityhealth care inequalityhealth care inequityimprovedin vivoinnovateinnovationinnovativeinsightlife year lossmachine based learningmalignancymodel of animalmolecular aberrationsmortalitymouse modelmurine modelmutant allelemutated in multiple advanced cancers 1 proteinneoplasm progressionneoplasm/cancerneoplastic progressionontogenyovarian cancerpathwayphosphatase and tensin homologue on chromosome tenprecancerprecancerouspremalignantprogramsrenalreproductive tractscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsnRNAsocial rolestructural mutationstructural variantstructural variationsurgerythree dimensionaltranscription factortranscriptional silencingtranscriptome sequencingtranscriptomic sequencingtranscriptomicstumortumor progressiontumor suppressortumorigenesisuRNAwombyears of life lost
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PROJECT SUMMARY/ABSTRACT
Endometrial cancer represents 7% of all cancer and is the 4th most common cancer in women, with 68,000 new cases
and 13,000 cancer-related deaths anticipated in 2024 in the USA. Annual deaths have been gradually increasing and are
now anticipated to be higher than ovarian cancer. Although surgery can cure early-stage…
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