grant

Mechanisms and consequences of lipid accumulations in necroptosis

Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AcylationAcyltransferaseAreaBindingCardiovascular DiseasesCell DeathCell FunctionCell Membrane PermeabilityCell PhysiologyCell ProcessCell membraneCellular FunctionCellular MembraneCellular PhysiologyCellular ProcessChronicChronic DiseaseChronic IllnessCytoplasmic MembraneDegenerative Neurologic DisordersDiseaseDisorderEC 2.3ElementsEnzyme GeneEnzymesFatty AcidsGeneticGoalsHealthHumanHuman PathologyInflammationInflammatoryInflammatory ResponseInvestigationIschemia-Reperfusion InjuryKinasesKnowledgeLaboratoriesLinkLipidsMediatingMembraneModern ManMolecularMolecular InteractionNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsPathway interactionsPermeabilityPhosphotransferase GenePhosphotransferasesPlasma MembraneProcessProductionProteinsProteomicsRegulationReperfusion DamageReperfusion InjuryResearchSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSterolsSubcellular ProcessTherapeuticTransphosphorylasesVery Long Chain Fatty Acidcardiovascular disorderchronic disorderdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesimaging approachimaging based approachlipidomicsmembrane permeabilitymembrane structurenecrocytosisneurodegenerative illnessnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwaypharmacologicplasmalemmaprotein function
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Project Summary
Lipids contribute to numerous cellular processes. The overarching goal of my laboratory is to study lipid regula-

tion and function in pathophysiological processes and identify targetable lipid-related pathways to better human

health. Necroptosis is a form of regulated cell death that contributes to the inflammatory components of…

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Mechanisms and consequences of lipid accumulations in necroptosis — STATE UNIVERSITY OF NEW YORK AT BUFFALO | UNITED STA | Dev Procure