grant
Mechanism of Toxin Mediated Damage to the Lung Epithelium during S. pneumoniae Infection
Organization SAN JOSE STATE UNIVERSITYLocation SAN JOSE, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AbscissionAdherens JunctionAdhering JunctionAdhesive JunctionAirAnchoring JunctionAntibodiesAspartic EndopeptidasesAspartic ProteinasesAspartyl ProteasesAspartyl ProteinasesBloodBlood Reticuloendothelial SystemCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCadherin-1Carboxyl (Acid) ProteinasesCarboxylic ProteinasesCas nuclease technologyCaspaseCaspase GeneCell BodyCell DeathCell JunctionsCell LineCell membraneCell-Death ProteaseCellLineCellsChelating AgentsChelatorsChemicalsCholesterolClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexonsComputer softwareConfocal MicroscopyCoon's TechnicCoon's TechniqueCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesCytolysinsCytoplasmic MembraneD pneumoniaeD. pneumoniaeDeath RateDiplococcus pneumoniaeDiseaseDisorderE-CadherinEpithelial Calcium-Dependent Adhesion ProteinEpithelial CellsEpithelial-CadherinEpitheliumEsteroproteasesEventExcisionExtirpationFinancial HardshipFluorescenceFluorescent Antibody TechnicFluorescent Antibody TechniqueFluorescent Antinuclear Antibody TestGenesGoalsHealthHospital AdmissionHospitalizationICE-like proteaseImageImage AnalysesImage AnalysisImmunoblottingImmunofluorescence TechnicImmunofluorescence TechniqueIndividualInfectionIntercellular JunctionsIonsKnock-outKnockoutLiquid substanceLungLung Respiratory SystemLung damageLung infectionsMeasuresMediatingMetallopeptidasesMetalloproteasesMetalloproteinasesModelingOccluding JunctionsOutcomePRR proteinPathogenicity FactorsPathway interactionsPatientsPeptidasesPeptide HydrolasesPlasma MembranePneumococcusPneumoniaPropidium DiiodidePropidium IodideProtease GeneProteasesProteinasesProteinsProteolytic EnzymesReaderRemovalResearchRespiratory infectious agentRespiratory tract pathogenRoleS pneumoniaeS. pneumoniaeSerine EndopeptidasesSerine ProteaseSerine Protein HydrolasesSerine ProteinasesSoftwareStaining methodStainsStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStrains Cell LinesStreptococcus pneumoniaeStreptococcus pneumoniae plY proteinSurgical RemovalSystemTight JunctionsToxinUvomorulinVirulence FactorsWestern BlottingWestern ImmunoblottingZonula Occludensafadinaspartate proteaseaspartic proteasecombatcultured cell linecystein proteasecystein proteinasecysteine endopeptidasedesigndesigningexperimentexperimental researchexperimental studyexperimentsfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial strainfinancial stressfluidfluorescent antibodygenetic approachgenetic strategyimage evaluationimage interpretationimaginginhibitorjunction adhesion moleculejunctional adhesion moleculeliquidlung injurymonolayermortality ratemortality ratiomutantnecrocytosisnectinnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoccludinpathwayplasmalemmapneumolysinprotein Eprotein blottingpulmonary damagepulmonary infectionspulmonary injurypulmonary tissue damagepulmonary tissue injuryquantitative imagingresectionrespiratory pathogensocial rolestatistical analysis
Description preview
Project Summary
Streptococcus pneumoniae causes over 150,000 hospitalizations annually in the U.S., with a mortality rate of 5-
7%, making the disease both a significant health and financial burden. A key virulence factor during S. pneumoniae
infection is pneumolysin (PLY), a cholesterol dependent cytolysin (CDC) that causes ion flux in host cells…
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