grant
Mechanism of F-18-fluorodeoxyglucarate accrual in myocardial injury
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202618-FDG18F- FDG18FDG2 Fluoro 2 deoxy D glucose2-Fluoro-2-deoxyglucoseAcidsAcuteAcute myocardial infarctAcute myocardial infarctionAddressAmyloidosisAssayAsystoleBindingBioassayBiological AssayBiologyBiopsyBody TissuesCD49e AntigensCardiacCardiac ArrestCardiac Muscle CellsCardiac MyocytesCardiac arteryCardiac infarctionCardiocyteCardiomyopathiesCell surfaceCell-Extracellular MatrixChargeChemicalsCicatrixClinicalClinical Drug DevelopmentClinical Drug Testing/DevelopmentClosure by LigationCold-Insoluble GlobulinsCollagenConsensusContracting OpportunitiesContractsCoronary arteryD-Glucaric AcidDataDepositDepositionDetectionDiagnosisDiagnostic ImagingDiagnostic MethodDiagnostic ProcedureDiagnostic TechniqueDoseDrugsECMEarly DiagnosisExtracellular MatrixFN1FNRAFibronectin 1Fibronectin ReceptorFibronectin Receptor Alpha SubunitFibronectin ReceptorsFibronectinsFibrosisFibrosis in the heartFibrosis in the myocardiumFibrosis within the heartFibrosis within the myocardiumFibrotic myocardiumGlucaric AcidGlucosaccharic AcidHeartHeart ArrestHeart InjuriesHeart Muscle CellsHeart arteryHeart failureHeart myocyteITGA5ITGA5 geneImageImaging technologyIndividualInfarctionInjuryIntegrin Alpha 5Integrin alpha5Integrin alphaFIntegrin α5IsoprenalineIsopropyl NoradrenalineIsopropylarterenolIsopropylnoradrenalineIsopropylnorepinephrineIsoproterenolIsuprelKO miceKnock-out MiceKnockout MiceLETS ProteinsLabelLarge External Transformation-Sensitive ProteinLife StyleLifestyleLigandsLigationMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMaximal Tolerated DoseMaximally Tolerated DoseMaximum Tolerated DoseMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMethodsMiceMice MammalsModelingMolecularMolecular InteractionMolecular TargetMonitorMurineMusMyocardialMyocardial DiseasesMyocardial DisorderMyocardial InfarctMyocardial InfarctionMyocardiopathiesMyocarditisMyocardiumNMR ImagingNMR TomographyNecrosisNecroticNon-Invasive DetectionNoninvasive DetectionNuclear Magnetic Resonance ImagingNull MouseOperative ProceduresOperative Surgical ProceduresOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOutcomeOxidantsOxidizing AgentsPETPET ScanPET imagingPETSCANPETTPathologicPatientsPharmaceutical PreparationsPhasePlatelet Glycoprotein IcPolymersPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPre-Clinical ModelPreclinical ModelsProductionProteinsPublishingQuality ControlRad.-PETRadiation DosimetryRadioactiveRadiometryRegression AnalysesRegression AnalysisRegression DiagnosticsRelaxationReportingResearchResidualResidual stateResolutionSampling ErrorsScarsSecondary toSiteSite-Directed MutagenesisSite-Specific MutagenesisStatistical RegressionStructureSurfaceSurface Plasmon ResonanceSurgicalSurgical InterventionsSurgical ProcedureTargeted DNA ModificationTargeted ModificationTechniquesTetrahydroxyadipic AcidTimeTissuesToxic effectToxicitiesToxicologyVLA-5 alpha ChainVLA5AZeugmatographyalpha 2-Surface Binding Glycoproteinalpha(5) Integrinamyloid diseaseantifibrotic agentantifibrotic medicationantifibrotic therapyantifibrotic treatmentattenuationcardiac failurecardiac fibrosiscardiac infarctcardiac inflammationcardiac injurycardiac musclecardiomyocyteclinical drug development/testingclinical translationclinically translatablecoronary attackcoronary fibrosiscoronary infarctcoronary infarctiondosimetrydrug/agentearly detectionelectron acceptorexpectationexperimentexperimental researchexperimental studyexperimentsfibrogenesisfibrotic heartfirst in manfirst-in-humanfluorodeoxyglucoseheart attackheart fibrosisheart infarctheart infarctionheart musclehigh definitionhigh-resolutionimagingimaging agentimproved outcomein vivoinfarctinjuriesinjury to the myocardiummyocardial biopsymyocardial fibrosismyocardial injurymyocardium diseasemyocardium disordernovelpolymerpolymericpolymerizationpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypreventpreventingradioassayradiolabelradiolabelsradiotracerrapid methodrapid techniqueresolutionsresponsescaffoldscaffoldingsurgeryuptake
Description preview
PROJECT SUMMARY
Each year millions of individuals suffer from heart ailments such as myocardial infarction (MI), myocarditis,
cardiomyopathies, etc. that lead to heart failure. Most heart failures are due to the loss of conductivity and
contractility secondary to fibrosis that develops as a common response to these cardiac conditions. Early…
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