grant
Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation
Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 1 Jan 2021Deadline 30 Nov 2030
NIHUS FederalResearch GrantFY20263-D3-D structure3-Dimensional3-dimensional structure3C-based approach3C-based assay3C-based method3C-based strategy3C-based technique3C-based technology3D3D structureAreaAutomobile DrivingBindingBinding SitesBudding YeastCell BodyCell NucleusCellsChemicalsChromatinChromatin StructureChromosomal OrganizationChromosomal StructureChromosome OrganizationChromosome StructuresChromosomesCombining SiteDiseaseDisorderEndomycetalesFoundationsGene Action RegulationGene Down-RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenomeGoalsHealthHeterochromatinHumanImageInvadedLinkMammalian CellMethodologyMethodsModern ManMolecular InteractionNuclearNucleosomesNucleusOligoOligonucleotidesPatternPhysical condensationPlayProcessReactive SiteRegulator GenesResearchRoleSaccharomycetalesSpecificityStructureTechnologyTherapeutic InterventionTranscription RepressionTranscriptional ControlTranscriptional RegulationTranscriptional Regulatory ElementsYeastschromatin conformation capturechromosome capturechromosome conformation capturecohesincondensationdetection methoddetection proceduredetection techniquedrivinggene repressiongenetic trans acting elementhuman diseaseimaginginnovateinnovationinnovativeinsightintervention therapyoligosprogramsregulatory genesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthree dimensionalthree dimensional structuretrans acting element
Description preview
Project Summary / Abstract
The overall theme of my research program is to unravel the mechanisms underlying chromatin structure and
understand its role in gene regulation. Our approach tackles this challenge on two interconnected levels: at the
chromatin / nucleosome level, we investigate the mechanisms driving nucleosome depletion and chromatin…
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